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Items: 1 to 20 of 63

1.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

(Submitter supplied) Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the Mixed Lineage Leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor prognosis leukemias. Here we find that MLL-AF4 occupies a subset of unmethylated CG-enriched genes in combination with its cofactors Menin/LEDGF and ENL. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL16791 GPL18573
59 Samples
Download data: BED, BW, TXT
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
4.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
5.

FBM_InputDNA

Organism:
Homo sapiens
Source name:
Fetal bone marrow
Platform:
GPL18573
Series:
GSE83671
Download data
Sample
Accession:
GSM2364556
ID:
302364556
6.

FBM_MLL_ChIPseq

Organism:
Homo sapiens
Source name:
Fetal bone marrow
Platform:
GPL18573
Series:
GSE83671
Download data: BED
Sample
Accession:
GSM2364555
ID:
302364555
7.

CB_InputDNA

Organism:
Homo sapiens
Source name:
Cord blood
Platform:
GPL18573
Series:
GSE83671
Download data
Sample
Accession:
GSM2364554
ID:
302364554
8.

CB_MLL_ChIPseq

Organism:
Homo sapiens
Source name:
Cord blood
Platform:
GPL18573
Series:
GSE83671
Download data: BED
Sample
Accession:
GSM2364553
ID:
302364553
9.

PT_InputDNA

Organism:
Homo sapiens
Source name:
L826
Platform:
GPL18573
Series:
GSE83671
Download data
Sample
Accession:
GSM2364552
ID:
302364552
10.

PT_AF4_ChIPseq

Organism:
Homo sapiens
Source name:
L826
Platform:
GPL18573
Series:
GSE83671
Download data: BED
Sample
Accession:
GSM2364551
ID:
302364551
11.

PT_MLL_ChIPseq

Organism:
Homo sapiens
Source name:
L826
Platform:
GPL18573
Series:
GSE83671
Download data: BED
Sample
Accession:
GSM2364550
ID:
302364550
12.

SEM_siMLL-AF4_InputDNA

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364549
ID:
302364549
13.

SEM_siMLL-AF4_AF4_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364548
ID:
302364548
14.

SEM_siMLL-AF4_MLL_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364547
ID:
302364547
15.

SEM_siControl_InputDNA

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364546
ID:
302364546
16.

SEM_siControl_AF4_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364545
ID:
302364545
17.

SEM_siControl_MLL_ChIPseq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BW
Sample
Accession:
GSM2364544
ID:
302364544
18.

SEM_MLL_Replicate_InputDNA

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data
Sample
Accession:
GSM2364543
ID:
302364543
19.

RCH_MLL_InputDNA

Organism:
Homo sapiens
Source name:
Leukemia cell line (RCH-ACV)
Platform:
GPL16791
Series:
GSE83671
Download data
Sample
Accession:
GSM2212262
ID:
302212262
20.

SEM_MLL_Replicate_ChIPSeq

Organism:
Homo sapiens
Source name:
Leukemia cell line (SEM)
Platform:
GPL18573
Series:
GSE83671
Download data: BED
Sample
Accession:
GSM2364542
ID:
302364542
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