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Items: 1 to 20 of 25

1.

High Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML

(Submitter supplied) Bromodomain and extra-terminal domain (BET) family inhibitors offer a new approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML) that are exceptionally sensitive to BET inhibitors. PRO-seq identified over 1400 genes showing impaired release of promoter-proximal paused RNA polymerases, including the stem cell factor receptor tyrosine kinase KIT that is mutated in t(8;21) AML. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL11154 GPL18573
22 Samples
Download data: BEDGRAPH, TXT
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

30min-JQ1-replicate2 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212050
ID:
302212050
5.

30min-JQ1-replicate1 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212049
ID:
302212049
6.

15min-JQ1-replicate2 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212048
ID:
302212048
7.

15min-JQ1-replicate1 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212047
ID:
302212047
8.

0min-JQ1-replicate2 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212046
ID:
302212046
9.

0min-JQ1-replicate1 (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL18573
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212045
ID:
302212045
10.

Input_for_H3K27ac (ChIP-exo)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data
Sample
Accession:
GSM2212054
ID:
302212054
11.

H3K27ac (ChIP-exo)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212053
ID:
302212053
12.

AML-JQ1 (PRO-seq)

Organism:
Homo sapiens
Source name:
primary acute myeloid leukemia patient cells
Platform:
GPL11154
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212052
ID:
302212052
13.

AML-DMSO (PRO-seq)

Organism:
Homo sapiens
Source name:
primary acute myeloid leukemia patient cells
Platform:
GPL11154
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212051
ID:
302212051
14.

MS417-3hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212044
ID:
302212044
15.

JQ1-3hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212043
ID:
302212043
16.

DMSO-3hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212042
ID:
302212042
17.

MS417-1hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212041
ID:
302212041
18.

JQ1-1hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212040
ID:
302212040
19.

DMSO-1hr (RNA-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: TXT
Sample
Accession:
GSM2212039
ID:
302212039
20.

MS417-3hr (PRO-seq)

Organism:
Homo sapiens
Source name:
t(8;21)-containing acute myeloid leukemia cell line
Platform:
GPL11154
Series:
GSE83660
Download data: BEDGRAPH
Sample
Accession:
GSM2212038
ID:
302212038
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Supplemental Content

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