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Items: 7

1.

A splicing switch of TEAD4 regulates Hippo-YAP signaling pathway to inhibit tumor proliferation

(Submitter supplied) Splicing dysregulations extensively occur in cancers, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signaling, a key pathway that regulates cell proliferation and organ size, is under control of a new splicing switch. We show that TEAD4, the transcription factor that mediates Hippo-YAP signaling, undergoes alternative splicing facilitated by the tumor suppressor RBM4, producing a truncated isoform, TEAD4-S, which lacks N-terminal DNA-binding domain but maintains YAP-interaction domain. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
5 Samples
Download data: MATRIX
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

YAP-RBM4

Organism:
Homo sapiens
Source name:
Lung carcinoma cells
Platform:
GPL18573
Series:
GSE80372
Download data
Sample
Accession:
GSM2125382
ID:
302125382
4.

YAP-TEAD305

Organism:
Homo sapiens
Source name:
Lung carcinoma cells
Platform:
GPL18573
Series:
GSE80372
Download data
Sample
Accession:
GSM2125381
ID:
302125381
5.

YAP-TEAD434

Organism:
Homo sapiens
Source name:
Lung carcinoma cells
Platform:
GPL18573
Series:
GSE80372
Download data
Sample
Accession:
GSM2125380
ID:
302125380
6.

YAP

Organism:
Homo sapiens
Source name:
Lung carcinoma cells
Platform:
GPL18573
Series:
GSE80372
Download data
Sample
Accession:
GSM2125379
ID:
302125379
7.

pCDNA-ctl

Organism:
Homo sapiens
Source name:
Lung carcinoma cells
Platform:
GPL18573
Series:
GSE80372
Download data
Sample
Accession:
GSM2125378
ID:
302125378
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Supplemental Content

db=gds|term=GSE80372[Accession]|query=1|qty=2|blobid=MCID_65e2b40155436807bf853c78|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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