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Items: 19

1.

MLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]

(Submitter supplied) Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP). Previous observations link the transcription-associated methyltransferase and oncoprotein MLL1 to the DDR, leading us to investigate the role of MLL1 in SASP expression. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
16 Samples
Download data: BW
Series
Accession:
GSE78141
ID:
200078141
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

H3 Mll1 KD OIS (MLL1 KD OIS H3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067938
ID:
302067938
5.

H3 WT OIS (SC OIS H3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067937
ID:
302067937
6.

H3 WT Control (SC H3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067936
ID:
302067936
7.

Input MLL1 KD OIS (MLL1 KD OIS Input)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067935
ID:
302067935
8.

Input WT OIS (SC OIS Input)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067934
ID:
302067934
9.

Input WT Control (SC Input)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067933
ID:
302067933
10.

H3K4me3 MLL1 KD OIS (MLL1 KD OIS H3K4me3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067932
ID:
302067932
11.

H3K4me3 WT OIS (SC OIS H3K4me3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067931
ID:
302067931
12.

H3K4me3 WT Control (SC H3K4me3)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067930
ID:
302067930
13.

gH2A.x MLL1 KD OIS (MLL1 KD OIS gH2A.x)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067929
ID:
302067929
14.

gH2A.x WT OIS (SC OIS gH2A.x)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067928
ID:
302067928
15.

gH2A.x WT Control (SC gH2A.x)

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL18573
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067927
ID:
302067927
16.

Input WT OIS 2

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL11154
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067942
ID:
302067942
17.

Input WT Control 2

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL11154
Series:
GSE78141 GSE78142
Download data
Sample
Accession:
GSM2067941
ID:
302067941
18.

gH2A.x WT OIS 2

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL11154
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067940
ID:
302067940
19.

gH2A.x WT Control 2

Organism:
Homo sapiens
Source name:
IMR90 Lung Fibroblasts
Platform:
GPL11154
Series:
GSE78141 GSE78142
Download data: BW
Sample
Accession:
GSM2067939
ID:
302067939
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Supplemental Content

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