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Items: 1 to 20 of 152

1.

p53 is a critical regulator of airway epithelial progenitor cell homeostasis.

(Submitter supplied) How progenitor cells regulate quiescence and differentiation is poorly understood. Here, we demonstrate that the tumor suppressor p53 regulates both proliferation and differentiation of club progenitor cells in the airway epithelium. We show that p53 loss decreases ciliated cell differentiation and increases the proliferative capacity of club progenitors, increasing epithelial cell density. p53 deficient progenitors generated a pseudostratified epithelium containing basal-like cells in vitro and contained an increased proportion of BASCs in vivo, suggesting that p53 suppresses multipotency during homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
150 Samples
Download data: TXT
Series
Accession:
GSE78045
ID:
200078045
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

p53_knock_out (d30_p53_10)

Organism:
Mus musculus
Source name:
lung_p53_knock_out
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200016
ID:
302200016
4.

p53_knock_out (d30_p53_8)

Organism:
Mus musculus
Source name:
lung_p53_knock_out
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200015
ID:
302200015
5.

p53_knock_out (d30_p53_7)

Organism:
Mus musculus
Source name:
lung_p53_knock_out
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200014
ID:
302200014
6.

wild_type (d30-wt-6_S2)

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200013
ID:
302200013
7.

wild_type (d30_wt_5_S10)

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200012
ID:
302200012
8.

wild_type (d30_wt_1)

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2200011
ID:
302200011
9.

WT-H8-1-C47_S17

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065564
ID:
302065564
10.

WT-H7-1-C46_S34

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065563
ID:
302065563
11.

WT-H3-1-C45_S49

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065562
ID:
302065562
12.

WT-H2-1-C44_S66

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065561
ID:
302065561
13.

WT-H12-1-C94_S10

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065560
ID:
302065560
14.

WT-H1-1-C43_S65

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065559
ID:
302065559
15.

WT-G9-1-C42_S8

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065558
ID:
302065558
16.

WT-G8-1-C41_S7

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065557
ID:
302065557
17.

WT-G7-1-C40_S25

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065556
ID:
302065556
18.

WT-G3-1-C39_S40

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065555
ID:
302065555
19.

WT-G2-1-C38_S57

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065554
ID:
302065554
20.

WT-G12-1-C88_S73

Organism:
Mus musculus
Source name:
lung_wild_type
Platform:
GPL19057
Series:
GSE78045
Download data
Sample
Accession:
GSM2065553
ID:
302065553
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Supplemental Content

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