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Items: 8

1.

Inhibition of BET protein BRD4 activity synergizes with cisplatin in ovarian cancer by targeting ALDH activity through an ALDH1A1 super-enhancer and the associated enhancer RNA

(Submitter supplied) The emergence of tumor cells with certain stem-like characteristics such as high aldehyde dehydrogenase (ALDH) activity contributes to chemotherapy resistance. Here we report that inhibition of the BET protein BRD4 potentiates the tumor suppressive effects of cisplatin by targeting ALDH activity. The clinically applicable small molecule BET inhibitor JQ1 synergized with cisplatin by suppressing the growth of epithelial ovarian cancer cells both in vitro and in vivo. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL11154
5 Samples
Download data: TXT
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

RNA-seq for JQ1-treated cells

Organism:
Homo sapiens
Source name:
JQ1-treated cells
Platform:
GPL18573
Series:
GSE77568
Download data
Sample
Accession:
GSM2054579
ID:
302054579
5.

RNA-seq for DMSO-treated cells

Organism:
Homo sapiens
Source name:
DMSO-treated cells
Platform:
GPL18573
Series:
GSE77568
Download data
Sample
Accession:
GSM2054578
ID:
302054578
6.

input control

Organism:
Homo sapiens
Source name:
input control
Platform:
GPL11154
Series:
GSE77568
Download data
Sample
Accession:
GSM2054577
ID:
302054577
7.

BRD4 CHIP-seq in JQ1-treated cells

Organism:
Homo sapiens
Source name:
JQ1-treated cells
Platform:
GPL11154
Series:
GSE77568
Download data
Sample
Accession:
GSM2054576
ID:
302054576
8.

BRD4 CHIP-seq in DMSO-treated cells

Organism:
Homo sapiens
Source name:
DMSO-treated cells
Platform:
GPL11154
Series:
GSE77568
Download data
Sample
Accession:
GSM2054575
ID:
302054575
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Supplemental Content

db=gds|term=GSE77568[Accession]|query=1|qty=2|blobid=MCID_666ebf6b6e9d376f235e9ef0|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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