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Items: 11

1.

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation, but resistant to temozolomide (FAIRE-seq)

(Submitter supplied) Introduction: Glioma stem cells isolated from human glioblastomas are resistant to radiation and cytotoxic chemotherapy and may drive tumor recurrence. Treatment efficacy may depend on the presence of glioma stem cells, expression of DNA repair enzymes such as methylguanine methyltransferase (MGMT), or transcriptome subtype. Methods: To model genetic alterations in the core signaling pathways of human glioblastoma, we induced conditional Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: BW
Series
Accession:
GSE73262
ID:
200073262
2.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
3.

TRP2-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889820
ID:
301889820
4.

TRP1-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889819
ID:
301889819
5.

TR3-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889818
ID:
301889818
6.

TR2-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889817
ID:
301889817
7.

TR1-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889816
ID:
301889816
8.

T1-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889815
ID:
301889815
9.

T2-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889814
ID:
301889814
10.

AC2-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889813
ID:
301889813
11.

AC1-FAIRE

Organism:
Mus musculus
Source name:
astrocytes
Platform:
GPL19057
Series:
GSE73262 GSE75592
Download data: BW
Sample
Accession:
GSM1889812
ID:
301889812
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Supplemental Content

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