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Items: 14

1.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival [RNA-Seq]

(Submitter supplied) The potential safety issues related to the acquisition of common genomic aberrations in hPSC cultures are well-recognized, but these risks have not been evaluated for sporadic mutations. Here, we explore whether a sporadic mutation that spontaneously arose in a hESC culture consisting of a single-copy deletion of chr17p13.1 would confer a survival advantage to the mutant cells. Compared to wild-type cells with two normal copies of the chr17p13.1 region, the mutant cells displayed a selective advantage when exposed to stressful conditions, and retained a higher percentage of pluripotent cells after two weeks of in vitro differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
12 Samples
Download data: XLSX
Series
Accession:
GSE70874
ID:
200070874
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

Wild-type2_3

Organism:
Homo sapiens
Source name:
Wild-type2_3
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821013
ID:
301821013
4.

Wild-type2_2

Organism:
Homo sapiens
Source name:
Wild-type2_2
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821012
ID:
301821012
5.

Wild-type2_1

Organism:
Homo sapiens
Source name:
Wild-type2_1
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821011
ID:
301821011
6.

Wild-type1_3

Organism:
Homo sapiens
Source name:
Wild-type1_3
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821010
ID:
301821010
7.

Wild-type1_2

Organism:
Homo sapiens
Source name:
Wild-type1_2
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821009
ID:
301821009
8.

Wild-type1_1

Organism:
Homo sapiens
Source name:
Wild-type1_1
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821008
ID:
301821008
9.

Mutant1_3

Organism:
Homo sapiens
Source name:
Mutant1_3
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821007
ID:
301821007
10.

Mutant1_2

Organism:
Homo sapiens
Source name:
Mutant1_2
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821006
ID:
301821006
11.

Mutant1_1

Organism:
Homo sapiens
Source name:
Mutant1_1
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821005
ID:
301821005
12.

Mutant2_3

Organism:
Homo sapiens
Source name:
Mutant2_3
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821004
ID:
301821004
13.

Mutant2_2

Organism:
Homo sapiens
Source name:
Mutant2_2
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821003
ID:
301821003
14.

Mutant2_1

Organism:
Homo sapiens
Source name:
Mutant2_1
Platform:
GPL16791
Series:
GSE70874 GSE70875
Download data
Sample
Accession:
GSM1821002
ID:
301821002
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Supplemental Content

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