GSE70671[Accession] - GEO DataSets - NCBI

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Select item 2000706711.

Epigenome Editing by CRISPR/Cas9 Repressors for Silencing of Distal Regulatory Elements

(Submitter supplied) Epigenome editing with the CRISPR/Cas9 platform is a promising technology to modulate gene expression to direct cell phenotype and to dissect the causal epigenetic mechanisms that direct gene regulation. Fusions of the nuclease-inactive dCas9 to the KRAB repressor domain (dCas9-KRAB) can effectively silence target gene expression. We targeted dCas9-KRAB to the HS2 enhancer, a distal regulatory element that orchestrates the expression of multiple globin genes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
30 Samples

Download data: BW

Series

Accession:: GSE70671

ID:: 200070671

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12243 Series
349957 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3018198943.

dCas9_KRAB_HS2_CR10_H3K9me3_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819894

ID:: 301819894

SRA Run Selector

Select item 3018198934.

dCas9_KRAB_HS2_CR10_H3K9me3_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819893

ID:: 301819893

SRA Run Selector

Select item 3018198925.

dCas9_KRAB_HS2_CR10_H3K9me3_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819892

ID:: 301819892

SRA Run Selector

Select item 3018198916.

dCas9_HS2_CR10_H3K9me3_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819891

ID:: 301819891

SRA Run Selector

Select item 3018198907.

dCas9_HS2_CR10_H3K9me3_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819890

ID:: 301819890

SRA Run Selector

Select item 3018198898.

dCas9_HS2_CR10_H3K9me3_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR10_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819889

ID:: 301819889

SRA Run Selector

Select item 3018198889.

dCas9_KRAB_HS2_CR4_H3K9me3_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819888

ID:: 301819888

SRA Run Selector

Select item 30181988710.

dCas9_KRAB_HS2_CR4_H3K9me3_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819887

ID:: 301819887

SRA Run Selector

Select item 30181988611.

dCas9_KRAB_HS2_CR4_H3K9me3_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819886

ID:: 301819886

SRA Run Selector

Select item 30181988512.

dCas9_HS2_CR4_H3K9me3_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819885

ID:: 301819885

SRA Run Selector

Select item 30181988413.

dCas9_HS2_CR4_H3K9me3_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819884

ID:: 301819884

SRA Run Selector

Select item 30181988314.

dCas9_HS2_CR4_H3K9me3_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_HS2_CR4_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819883

ID:: 301819883

SRA Run Selector

Select item 30181988215.

dCas9_KRAB_H3K9me3_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819882

ID:: 301819882

SRA Run Selector

Select item 30181988116.

dCas9_KRAB_H3K9me3_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819881

ID:: 301819881

SRA Run Selector

Select item 30181988017.

dCas9_KRAB_H3K9me3_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_H3K9me3

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819880

ID:: 301819880

SRA Run Selector

Select item 30181987918.

dCas9_KRAB_HS2_CR10_FLAG_rep3

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_FLAG

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819879

ID:: 301819879

SRA Run Selector

Select item 30181987819.

dCas9_KRAB_HS2_CR10_FLAG_rep2

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_FLAG

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819878

ID:: 301819878

SRA Run Selector

Select item 30181987720.

dCas9_KRAB_HS2_CR10_FLAG_rep1

Organism:: Homo sapiens

Source name:: Cultured K562 cells_dCas9_KRAB_HS2_CR10_FLAG

Platform:: GPL16791
Series:: GSE70671

Download data: BW

Sample

Accession:: GSM1819877

ID:: 301819877

SRA Run Selector

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