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Items: 11

1.

Comparison of the transcriptome and chromatin state between human cord blood HSC and human iPSC derived hematopoietic progenitor using next-generation sequencing

(Submitter supplied) We analyzed the transcriptome and transposase accessible chromatin–using RNAseq and ATAC-seq, respectively–of human cord blood hematopoietic stem cells and human iPSC derived hematopoietic progenitors. iPSC-derived HPCs were FACS sorted CD34+/CD43+ cells. We also examined the effect of inhibiting Wnt signaling during the second week of hematopoietic differentiation of hiPSC. The integrated transcriptomic, epigenomic and functional analyses not only uncovered novel molecular differences between hPSC- HPCs and native HSCs, but also enabled us to target these differences with small molecules to improve derivation and function of hPSC derived HPCs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
9 Samples
Download data: BED, TXT
Series
Accession:
GSE69932
ID:
200069932
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

iPSC-HPC-RNAseq-r2

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713296
ID:
301713296
4.

iPSC-HPC-RNAseq-r1

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713295
ID:
301713295
5.

CB-HSPC-RNAseq-r2

Organism:
Homo sapiens
Source name:
hematopoietic stem/progenitor cell from cord blood
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713294
ID:
301713294
6.

CB-HSPC-RNAseq-r1

Organism:
Homo sapiens
Source name:
hematopoietic stem/progenitor cell from cord blood
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713293
ID:
301713293
7.

CB-HSPC_ATACseq

Organism:
Homo sapiens
Source name:
hematopoietic stem/progenitor cell from cord blood
Platform:
GPL16791
Series:
GSE69932
Download data: BED
Sample
Accession:
GSM1713292
ID:
301713292
8.

iPSC-HPC-IWR1_ATACseq

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data: BED
Sample
Accession:
GSM1713291
ID:
301713291
9.

iPSC-HPC-DMSO_ATACseq

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data: BED
Sample
Accession:
GSM1713290
ID:
301713290
10.

iPSC-HPC-IWR1_RNAseq

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713289
ID:
301713289
11.

iPSC-HPC-DMSO_RNAseq

Organism:
Homo sapiens
Source name:
hematopoietic progenitor cell derived from iPSC
Platform:
GPL16791
Series:
GSE69932
Download data
Sample
Accession:
GSM1713288
ID:
301713288
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Supplemental Content

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