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Items: 1 to 20 of 112

1.

Small and large RNA sequencing of mouse livers receiving small hairpin RNAs

(Submitter supplied) Adeno-associated viral (AAV) small hairpin (shRNA) expression vectors are a promising therapeutic but can induce severe liver toxicity when delivered at high albeit undefined doses. Using various AAV-shRNA vectors under the high-expressing U6 and low-expressing H1 promoters, we found that dose-limiting toxicity was strongly correlated with an shRNA concentration of >12% of total microRNA levels. Toxicity was associated with a specific reduction in the first synthesized 22nt isoform of miR-122-5p, resulting in the specific de-repression of miR-122 target mRNAs. more...
Organism:
Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
4 related Platforms
107 Samples
Download data: TXT
Series
Accession:
GSE69186
ID:
200069186
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
4.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
5.

Illumina Genome Analyzer II (Mus musculus)

Platform
Accession:
GPL9250
ID:
100009250
6.

het_U6_shHCV_1m

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079828
ID:
302079828
7.

het_U6_hAAT_7d_rep2

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079827
ID:
302079827
8.

het_U6_hAAT_7d_rep1

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079826
ID:
302079826
9.

miR122_floxed_Cre_7d

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079825
ID:
302079825
10.

miR122_floxed_uninjected

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079824
ID:
302079824
11.

miR122_floxed_Cre_3d

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079823
ID:
302079823
12.

het_uninjected_rep3

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079822
ID:
302079822
13.

het_U6_shHCV_7d_rep2

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079821
ID:
302079821
14.

het_uninjected_rep2

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079820
ID:
302079820
15.

het_uninjected_rep1

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079819
ID:
302079819
16.

het_U6_shHCV_7d_rep1

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079818
ID:
302079818
17.

miR122_floxed_Cre_14d

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079817
ID:
302079817
18.

miR122_floxed_Cre_6w

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079816
ID:
302079816
19.

het_U6_hAAT_2mo

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM2079815
ID:
302079815
20.

miR_122KO_HCV_21nt_d21

Organism:
Mus musculus
Source name:
liver - total RNA
Platform:
GPL16417
Series:
GSE69186
Download data
Sample
Accession:
GSM1695083
ID:
301695083
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