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Items: 3

1.

Activation of proto-oncogenes by disruption of chromosome neighborhoods [RNA-Seq]

(Submitter supplied) Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
1 Sample
Download data: WIG
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

Jurkat_polyA_RNA-Seq

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE68975 GSE68978
Download data: WIG
Sample
Accession:
GSM1689150
ID:
301689150
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Supplemental Content

db=gds|term=GSE68975[Accession]|query=1|qty=2|blobid=MCID_661b19bae3fccf29378041bf|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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