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Items: 16

1.

Distinct murine mucosal Langerhans cell subsets develop from pre-DCs and monocytes

(Submitter supplied) Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. In contrast to skin LCs originating from self-renewing radioresistant embryonic precursors, we found that oral mucosal LCs derive from circulating radiosensitive precursors. Mucosal LCs can be segregated into CD103+CD11blow (CD103+LCs) and CD11b+CD103- (CD11b+LCs) subsets. We further demonstrated that similar to non-lymphoid dendritic cells (DCs), CD103+LCs originate from pre-DCs, whereas CD11b+LCs differentiate from both pre-DCs and monocytic precursors. Despite this ontogenetic discrepancy between skin and mucosal LCs, transcriptomic signature and immunological function of oral LCs highly resemble those of skin LCs but not DCs. These findings, along with their epithelial position, morphology and expression of LC-associated phenotype strongly suggest that oral mucosal LCs are genuine LCs. Collectively, in a tissue-dependent manner, murine LCs differentiate from at least three distinct precursors (embryonic, pre-DCs and monocytic) in steady state
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
14 Samples
Download data: TXT
Series
Accession:
GSE68789
ID:
200068789
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

b17_lung_mac2_Expr2

Organism:
Mus musculus
Source name:
Lung macrophages
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681447
ID:
301681447
4.

b02_lung_Expr2

Organism:
Mus musculus
Source name:
Lung macrophages
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681446
ID:
301681446
5.

Skin_Langerhans_cells_Rep2

Organism:
Mus musculus
Source name:
Skin LCs
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681445
ID:
301681445
6.

Skin_Langerhans_cells_Rep1

Organism:
Mus musculus
Source name:
Skin LCs
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681444
ID:
301681444
7.

Mucosal_CD11b_P_LC_Rep4

Organism:
Mus musculus
Source name:
Mucosal LCs CD11b+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681443
ID:
301681443
8.

Mucosal_CD11b_P_LC_Rep3

Organism:
Mus musculus
Source name:
Mucosal LCs CD11b+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681442
ID:
301681442
9.

Mucosal_CD11b_P_LC_Rep2

Organism:
Mus musculus
Source name:
Mucosal LCs CD11b+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681441
ID:
301681441
10.

Mucosal_CD11b_P_LC_Rep1

Organism:
Mus musculus
Source name:
Mucosal LCs CD11b+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681440
ID:
301681440
11.

Mucosal_CD103_P_LC_Rep4

Organism:
Mus musculus
Source name:
Mucosal LCs CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681439
ID:
301681439
12.

Mucosal_CD103_P_LC_Rep3

Organism:
Mus musculus
Source name:
Mucosal LCs CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681438
ID:
301681438
13.

Mucosal_CD103_P_LC_Rep2

Organism:
Mus musculus
Source name:
Mucosal LCs CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681437
ID:
301681437
14.

Mucosal_CD103_P_LC_Rep1

Organism:
Mus musculus
Source name:
Mucosal LCs CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681436
ID:
301681436
15.

Lungs_Langerin_P_CD103_P_Rep2

Organism:
Mus musculus
Source name:
Lung DCs Langerin+ CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681435
ID:
301681435
16.

Lungs_Langerin_P_CD103_P_Rep1

Organism:
Mus musculus
Source name:
Lung DCs Langerin+ CD103+
Platform:
GPL18480
Series:
GSE68789
Download data
Sample
Accession:
GSM1681434
ID:
301681434
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Supplemental Content

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