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Items: 7

1.

A biogenesis step upstream of Microprocessor controls miR-17~92 expression

(Submitter supplied) The precise control of miR-17~92 microRNA (miRNA) is essential for normal development and overexpression of certain miRNAs from this cluster is oncogenic. Here we find the relative expression of the six miRNAs processed from the primary (pri-miR-17~92) transcript is dynamically regulated during embryonic stem cell differentiation. We identify a new miRNA biogenesis intermediate, termed ‘progenitor-miRNA’ (pro-miRNA), that is an efficient substrate for Microprocessor. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL13112 GPL16417
4 Samples
Download data: TXT
Series
Accession:
GSE68699
ID:
200068699
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

Illumina HiSeq 2000 (Mus musculus)

Platform
Accession:
GPL13112
ID:
100013112
4.

WT_small RNA seq

Organism:
Mus musculus
Source name:
mESCs
Platform:
GPL13112
Series:
GSE68699
Download data
Sample
Accession:
GSM1679301
ID:
301679301
5.

dicer-/-_RNAseq

Organism:
Mus musculus
Source name:
mESCs
Platform:
GPL16417
Series:
GSE68699
Download data
Sample
Accession:
GSM1679300
ID:
301679300
6.

dgcr8-/-_RNAseq

Organism:
Mus musculus
Source name:
mESCs
Platform:
GPL16417
Series:
GSE68699
Download data
Sample
Accession:
GSM1679299
ID:
301679299
7.

WT_RNAseq

Organism:
Mus musculus
Source name:
mESCs
Platform:
GPL16417
Series:
GSE68699
Download data
Sample
Accession:
GSM1679298
ID:
301679298
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Supplemental Content

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