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Items: 1 to 20 of 72

1.

RNAseq changes in pre MAPKi treatment and post MAPKi resistance Melanomas

(Submitter supplied) Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors revealed key driver genes but failedto adequately account for clinical resistance. From a large-scale comparative analysis of temporal transcriptomes from patient-matched tumor biopsies, we discovered highly recurrent differential expression and signature outputs of c-MET, LEF1 and YAP1 as drivers of acquired MAPK inhibitor resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
70 Samples
Download data: TXT
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

SKMel28DDR1-PLXAZD

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588921
ID:
301588921
4.

SKMel28R1-PLX

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588920
ID:
301588920
5.

SKMel28-DMSO

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588919
ID:
301588919
6.

M238R1-PLX

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588918
ID:
301588918
7.

M238-DMSO2D

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588917
ID:
301588917
8.

M229DDRpoly-PLXAZD

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588916
ID:
301588916
9.

M229R5-PLX

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588915
ID:
301588915
10.

M229-DMSO2D

Organism:
Homo sapiens
Source name:
Melanoma cell line
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588914
ID:
301588914
11.

Pt24-DDP1

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588913
ID:
301588913
12.

Pt24-baseline

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588912
ID:
301588912
13.

Pt23-DDP1

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588911
ID:
301588911
14.

Pt23-baseline

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588910
ID:
301588910
15.

Pt22-DDP3

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588909
ID:
301588909
16.

Pt22-DDP2

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588908
ID:
301588908
17.

Pt22-DDP1

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588907
ID:
301588907
18.

Pt22-baseline

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588906
ID:
301588906
19.

Pt21-DP2

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588905
ID:
301588905
20.

Pt21-DDP2

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL11154
Series:
GSE65185 GSE65186
Download data
Sample
Accession:
GSM1588904
ID:
301588904
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Supplemental Content

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