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Items: 6

1.

Expression changes in pre MAPKi treatment and post MAPKi resistance Melanomas

(Submitter supplied) Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors revealed key driver genes but failedto adequately account for clinical resistance. From a large-scale comparative analysis of temporal transcriptomes from patient-matched tumor biopsies, we discovered highly recurrent differential expression and signature outputs of c-MET, LEF1 and YAP1 as drivers of acquired MAPK inhibitor resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17692
4 Samples
Download data: CEL
Series
Accession:
GSE65184
ID:
200065184
2.

[HuGene-2_1-st] Affymetrix Human Gene 2.1 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html September 06, 2013: HuGene-2_1-st-v1.na33.2.hg19.transcript.csv Protocol: See manufacturer's web site
Organism:
Homo sapiens
210 Series
6 Related Platforms
5136 Samples
Download data
Platform
Accession:
GPL17692
ID:
100017692
3.

Pt7-DP1.replicate

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL17692
Series:
GSE65184 GSE65186
Download data: CEL
Sample
Accession:
GSM1588851
ID:
301588851
4.

Pt7-DP1

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL17692
Series:
GSE65184 GSE65186
Download data: CEL
Sample
Accession:
GSM1588850
ID:
301588850
5.

Pt7-baseline.replicate

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL17692
Series:
GSE65184 GSE65186
Download data: CEL
Sample
Accession:
GSM1588849
ID:
301588849
6.

Pt7-baseline

Organism:
Homo sapiens
Source name:
tumor biopsy
Platform:
GPL17692
Series:
GSE65184 GSE65186
Download data: CEL
Sample
Accession:
GSM1588848
ID:
301588848
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Supplemental Content

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