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Items: 1 to 20 of 84

1.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites [sequencing]

(Submitter supplied) Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we identify the protein network around chromatin-bound GR by using selective isolation of chromatin-associated proteins and show that the network is affected by receptor SUMOylation, with several nuclear receptor coregulators and chromatin modifiers preferring interaction with SUMOylation-deficient GR and proteins implicated in transcriptional repression preferring interaction with SUMOylation-competent GR. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
81 Samples
Download data: BEDGRAPH
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

HEK293flpGR3KR_RNAseq_ML792-Dex_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955604
ID:
304955604
5.

HEK293flpGR3KR_RNAseq_ML792-Dex_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955603
ID:
304955603
6.

HEK293flpGR3KR_RNAseq_ML792-EtOH_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955602
ID:
304955602
7.

HEK293flpGR3KR_RNAseq_ML792-EtOH_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955601
ID:
304955601
8.

HEK293flpGR3KR_RNAseq_DMSO-Dex_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955600
ID:
304955600
9.

HEK293flpGR3KR_RNAseq_DMSO-Dex_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955599
ID:
304955599
10.

HEK293flpGR3KR_RNAseq_DMSO-EtOH_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955598
ID:
304955598
11.

HEK293flpGR3KR_RNAseq_DMSO-EtOH_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955597
ID:
304955597
12.

HEK293flpGR_RNAseq_ML792-Dex_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, ML-792 + dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955596
ID:
304955596
13.

HEK293flpGR_RNAseq_ML792-Dex_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, ML-792 + dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955595
ID:
304955595
14.

HEK293flpGR_RNAseq_ML792-EtOH_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, ML-792 + vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955594
ID:
304955594
15.

HEK293flpGR_RNAseq_ML792-EtOH_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, ML-792 + vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955593
ID:
304955593
16.

HEK293flpGR_RNAseq_DMSO-Dex_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955592
ID:
304955592
17.

HEK293flpGR_RNAseq_DMSO-Dex_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, dex, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955591
ID:
304955591
18.

HEK293flpGR_RNAseq_DMSO-EtOH_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955590
ID:
304955590
19.

HEK293flpGR_RNAseq_DMSO-EtOH_rep1

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, wild-type GR, vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955589
ID:
304955589
20.

HEK293flpGR3KR_GR_ML792-Dex_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), ML-792 + dex, GR ChIP
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955588
ID:
304955588
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Supplemental Content

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