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Items: 8

1.

Meis1 coordinates a network of genes implicated in eye development and microphthalmia

(Submitter supplied) Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degrees. Sporadic and hereditary microphthalmos has been associated to heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identification of molecular causes. Here we show that haploinsufficiency of Meis1, a transcription factor with an evolutionary conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual impairment, in adult mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL11002
5 Samples
Download data: BED, TXT
Series
Accession:
GSE62786
ID:
200062786
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
4.

Meis1_ChIP-seq

Organism:
Mus musculus
Source name:
mouse optic cups_WT_ChIP
Platform:
GPL11002
Series:
GSE62786
Download data: BED
Sample
Accession:
GSM1533394
ID:
301533394
5.

WT_RNA-seq

Organism:
Mus musculus
Source name:
mouse optic cups_WT
Platform:
GPL11002
Series:
GSE62786
Download data
Sample
Accession:
GSM1533393
ID:
301533393
6.

KO_RNA-seq

Organism:
Mus musculus
Source name:
mouse optic cups_KO
Platform:
GPL11002
Series:
GSE62786
Download data
Sample
Accession:
GSM1533392
ID:
301533392
7.

H3k4me3 Eye ChIPSeq

Organism:
Mus musculus
Source name:
100 eyes from E10.5 mouse embryos
Platform:
GPL17021
Series:
GSE62786
Download data: BED
Sample
Accession:
GSM1695384
ID:
301695384
8.

H3k4me1 Eye ChIPSeq

Organism:
Mus musculus
Source name:
100 eyes from E10.5 mouse embryos
Platform:
GPL17021
Series:
GSE62786
Download data: BED
Sample
Accession:
GSM1695383
ID:
301695383
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Supplemental Content

db=gds|term=GSE62786[Accession]|query=1|qty=2|blobid=MCID_6677e7dfccfbad768fc5c3f6|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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