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1.

Molecular signatures of heterogeneous stem cell populations are resolved by linking single cell functional assays to single cell gene expression

(Submitter supplied) The discovery of significant heterogeneity in the self-renewal durability of adult haematopoietic stem cells (HSCs) has challenged our understanding of the molecules involved in population maintenance throughout life. Gene expression studies in bulk populations are difficult to interpret since multiple HSC subtypes are present and HSC purity is typically less than 50% of the input cell population. Numerous groups have therefore turned to studying gene expression profiles of single HSCs, but again these studies are limited by the purity of the input fraction and an inability to directly ascribe a molecular program to a durable self-renewing HSC. Here we combine single cell functional assays with flow cytometric index sorting and single cell gene expression assays to gain the first insight into the gene expression program of HSCs that possess durable self-renewal. This approach can be used in other stem cell systems and sets the stage for linking key molecules with defined cellular functions.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
96 Samples
Download data: XLS
Series
Accession:
GSE61533
ID:
200061533
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

haematopoietic stem cell [HSC1_96]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507658
ID:
301507658
4.

haematopoietic stem cell [HSC1_95]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507657
ID:
301507657
5.

haematopoietic stem cell [HSC1_94]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507656
ID:
301507656
6.

haematopoietic stem cell [HSC1_93]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507655
ID:
301507655
7.

haematopoietic stem cell [HSC1_92]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507654
ID:
301507654
8.

haematopoietic stem cell [HSC1_91]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507653
ID:
301507653
9.

haematopoietic stem cell [HSC1_90]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507652
ID:
301507652
10.

haematopoietic stem cell [HSC1_89]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507651
ID:
301507651
11.

haematopoietic stem cell [HSC1_88]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507650
ID:
301507650
12.

haematopoietic stem cell [HSC1_87]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507649
ID:
301507649
13.

haematopoietic stem cell [HSC1_86]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507648
ID:
301507648
14.

haematopoietic stem cell [HSC1_85]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507647
ID:
301507647
15.

haematopoietic stem cell [HSC1_84]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507646
ID:
301507646
16.

haematopoietic stem cell [HSC1_83]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507645
ID:
301507645
17.

haematopoietic stem cell [HSC1_82]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507644
ID:
301507644
18.

haematopoietic stem cell [HSC1_81]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507643
ID:
301507643
19.

haematopoietic stem cell [HSC1_80]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507642
ID:
301507642
20.

haematopoietic stem cell [HSC1_79]

Organism:
Mus musculus
Source name:
Bone marrow
Platform:
GPL17021
Series:
GSE61533
Download data
Sample
Accession:
GSM1507641
ID:
301507641
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Supplemental Content

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