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Items: 5

1.

The functional impact of RNA Polymerase II pausing across multiple mamamlian cell types

(Submitter supplied) We analyzed the breadth and functional relationships of RNA Polymerase II pausing across many human and mouse cell types to understand what roles RNA Polymerase II pausing plays in gene regulation. We identified a novel association of H2A.Z at the TSS of increasingly paused genes. We knocked down H2A.Z to test whether H2A.Z positively or negatively affects RNA Polymerase II pausing to find that pausing globally increased upon knockdown.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
3 Samples
Download data: CSV
Series
Accession:
GSE60872
ID:
200060872
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

Input

Organism:
Homo sapiens
Source name:
MCF7 cell line
Platform:
GPL16791
Series:
GSE60872
Download data: CSV
Sample
Accession:
GSM1492703
ID:
301492703
4.

Pol II H2AZ knockdown

Organism:
Homo sapiens
Source name:
MCF7 cell line
Platform:
GPL16791
Series:
GSE60872
Download data: CSV
Sample
Accession:
GSM1492702
ID:
301492702
5.

Pol II Control

Organism:
Homo sapiens
Source name:
MCF7 cell line
Platform:
GPL16791
Series:
GSE60872
Download data: CSV
Sample
Accession:
GSM1492701
ID:
301492701
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Supplemental Content

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