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Items: 13

1.

Drug specific epigenetic reprogramming leads to increased cellular invasion in ERα positive breast cancer via de novo cholesterol biosynthesis.

(Submitter supplied) Endocrine therapy resistance remains a critical problem in the treatment of estrogen receptor alpha (ERα) breast cancer. Endocrine therapies target ERα via different modes of action. Drug resistance involves drug specific remodeling of the transcriptional and regulatory landscape. Using epigenomics and transcriptomics, we demonstrate that resistance to aromatase inhibitors (AI) induces phenotypical changes through epigenetic activation of cholesterol biosynthesis (CB) and keratin 80. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154
10 Samples
Download data: BED, WIG
Series
Accession:
GSE60517
ID:
200060517
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

ERalpha ChIP-seq LTED Tamoxifen resistant cells

Organism:
Homo sapiens
Source name:
LTED breast cancer cells, Tamoxifen resistant
Platform:
GPL16791
Series:
GSE60517
Download data: BED
Sample
Accession:
GSM2061659
ID:
302061659
5.

ERalpha ChIP-seq LTED cells

Organism:
Homo sapiens
Source name:
LTED breast cancer cells
Platform:
GPL16791
Series:
GSE60517
Download data: BED
Sample
Accession:
GSM2061658
ID:
302061658
6.

ERalpha ChIP-seq MCF7 Tamoxifen resistant cells

Organism:
Homo sapiens
Source name:
MCF7 breast cancer cells, Tamoxifen resistant
Platform:
GPL16791
Series:
GSE60517
Download data: BED
Sample
Accession:
GSM2061657
ID:
302061657
7.

Eralpha ChIP-seq MCF7 cells

Organism:
Homo sapiens
Source name:
MCF7 breast cancer cells
Platform:
GPL16791
Series:
GSE60517
Download data: BED
Sample
Accession:
GSM2061656
ID:
302061656
8.

H3K27ac LTEDF

Organism:
Homo sapiens
Source name:
LTEDF
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481575
ID:
301481575
9.

H3K27ac LTEDT

Organism:
Homo sapiens
Source name:
LTEDT
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481574
ID:
301481574
10.

H3K27ac LTED

Organism:
Homo sapiens
Source name:
LTED
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481573
ID:
301481573
11.

H3K27ac MCF7F

Organism:
Homo sapiens
Source name:
MCF7F
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481572
ID:
301481572
12.

H3K27ac MCF7T

Organism:
Homo sapiens
Source name:
MCF7T
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481571
ID:
301481571
13.

H3K27ac MCF7

Organism:
Homo sapiens
Source name:
MCF7 cells
Platform:
GPL11154
Series:
GSE60517
Download data: WIG
Sample
Accession:
GSM1481570
ID:
301481570
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Supplemental Content

db=gds|term=GSE60517[Accession]|query=1|qty=2|blobid=MCID_65d5f4508e7da52507af0bf4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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