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Items: 1 to 20 of 24

1.

An Oncogenic Super-Enhancer Formed through Somatic Mutation of a Noncoding Intergenic Element

(Submitter supplied) In many cancers, critical oncogenes are driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive H3K27 acetylation. We found that in T-cell acute lymphoblastic leukemia (T-ALL), somatic heterozygous mutations introduce MYB binding motifs in a precise noncoding site, which nucleate a super-enhancer upstream of the TAL1 oncogene. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16791 GPL11154 GPL9115
20 Samples
Download data: WIG
Series
Accession:
GSE59657
ID:
200059657
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Illumina Genome Analyzer II (Homo sapiens)

Platform
Accession:
GPL9115
ID:
100009115
5.

ChIP:H3K27ac_ab4729_Jurkat3_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519642
ID:
301519642
6.

ChIP:MYB_ab45150_Jurkat3_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519641
ID:
301519641
7.

Input for ChIP:Jurkat3_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519640
ID:
301519640
8.

ChIP:MYB_ab45150_Jurkat4_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519639
ID:
301519639
9.

ChIP:H3K27ac_ab4729_Jurkat1_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519638
ID:
301519638
10.

Input for ChIP:Jurkat1_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519637
ID:
301519637
11.

Input for ChIP:Jurkat4_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519636
ID:
301519636
12.

ChIP:MYB_ab45150_Jurkat1_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519635
ID:
301519635
13.

ChIP:H3K27ac_ab4729_Jurkat4_091914 [lab: Look-DFCI]

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL16791
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519634
ID:
301519634
14.

ChIP:TAL1_sc12984_MOLT3_062714

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519646
ID:
301519646
15.

Input for ChIP:MOLT3_062714

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519645
ID:
301519645
16.

ChIP:H3K27ac_ab4729_MOLT3_062714

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519644
ID:
301519644
17.

ChIP:vMYB_ab45150_MOLT3_062714

Organism:
Homo sapiens
Source name:
T-ALL
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1519643
ID:
301519643
18.

Input for ChIP:MYB_Jurkat_040314 04182014_C4JDGACXX_6.CAGATC

Organism:
Homo sapiens
Source name:
T-ALL cell line
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1442007
ID:
301442007
19.

ChIP:MYB_ab45150_Jurkat_040314 04182014_C4JDGACXX_6.ACAGTG

Organism:
Homo sapiens
Source name:
T-ALL cell line
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1442006
ID:
301442006
20.

ChIP:MYB_05-175_Jurkat_040314 04182014_C4JDGACXX_6.GCCAAT

Organism:
Homo sapiens
Source name:
T-ALL cell line
Platform:
GPL11154
Series:
GSE59657
Download data: WIG
Sample
Accession:
GSM1442005
ID:
301442005
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Supplemental Content

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