U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 13

1.

The Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination

(Submitter supplied) The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone modification. Using tandem affinity purification and mass spectrometry, we find that MED23 associates with the RNF20/40 complex, the enzyme for H2Bub, and show that this association is critical for the recruitment of RNF20/40 to chromatin. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
10 Samples
Download data: WIG
Series
Accession:
GSE59518
ID:
200059518

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Mus musculus)

Organism:
Mus musculus
8067 Series
183768 Samples
Download data
Platform
Accession:
GPL13112
ID:
100013112

3.

Illumina Genome Analyzer IIx (Mus musculus)

Organism:
Mus musculus
890 Series
7694 Samples
Download data
Platform
Accession:
GPL11002
ID:
100011002

4.

H3K79me3_KO_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells knockout MED23
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1833649
ID:
301833649

SRA Run Selector

5.

H3K79me3_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1833648
ID:
301833648

SRA Run Selector

6.

H3K4me3_KO_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells knockout MED23
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1833647
ID:
301833647

SRA Run Selector

7.

H3K4me3_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1833646
ID:
301833646

SRA Run Selector

8.

input_KO_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells knockout MED23
Platform:
GPL11002
Series:
GSE59518
Download data
Sample
Accession:
GSM1438702
ID:
301438702

SRA Run Selector

9.

input_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL11002
Series:
GSE59518
Download data
Sample
Accession:
GSM1438701
ID:
301438701

SRA Run Selector

10.

pol2_KO_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells knockout MED23
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1438698
ID:
301438698

SRA Run Selector

11.

pol2_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL11002
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1438697
ID:
301438697

SRA Run Selector

12.

h2bub_KO_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells knockout MED23
Platform:
GPL13112
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1438700
ID:
301438700

SRA Run Selector

13.

h2bub_WT_ChIPSeq

Organism:
Mus musculus
Source name:
MEFs cells wildtype
Platform:
GPL13112
Series:
GSE59518
Download data: WIG
Sample
Accession:
GSM1438699
ID:
301438699

SRA Run Selector

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filters: Manage Filters

db=gds|term=GSE59518[Accession]|query=1|qty=2|blobid=MCID_6567e6a1c74a38335432090c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Important Links

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets
Support Center