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Items: 17

1.

Epigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Histone modifications associated with gene silencing typically mark large contiguous regions of the genome forming repressive chromatin domain structures. Since the repressive domains exist in close proximity to active regions, maintenance of domain structure is critically important. This study shows that nickel, a nonmutagenic carcinogen, can disrupt histone H3 lysine 9 dimethylation (H3K9me2) domain structures genome-wide, resulting in spreading of H3K9me2 marks into the active regions, which is associated with gene silencing. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL16791
14 Samples
Download data: BED
Series
Accession:
GSE56053
ID:
200056053
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

Input_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data
Sample
Accession:
GSM1354441
ID:
301354441
5.

Input_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data
Sample
Accession:
GSM1354440
ID:
301354440
6.

H3K27me3_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354435
ID:
301354435
7.

H3K27me3_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354434
ID:
301354434
8.

H3K9me2_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354433
ID:
301354433
9.

H3K9me2_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354432
ID:
301354432
10.

H3K4me3_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354431
ID:
301354431
11.

H3K4me3_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL11154
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354430
ID:
301354430
12.

RNASeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56052 GSE56053
Download data
Sample
Accession:
GSM1354443
ID:
301354443
13.

RNASeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56052 GSE56053
Download data
Sample
Accession:
GSM1354442
ID:
301354442
14.

CTCF_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354439
ID:
301354439
15.

CTCF_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354438
ID:
301354438
16.

H3K9ac_ChIPSeq_Nickel

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354437
ID:
301354437
17.

H3K9ac_ChIPSeq_Control

Organism:
Homo sapiens
Source name:
BEAS-2B cells
Platform:
GPL16791
Series:
GSE56051 GSE56053
Download data: BED
Sample
Accession:
GSM1354436
ID:
301354436
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Supplemental Content

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