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Items: 4

1.

Neuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]

(Submitter supplied) Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired mutation of Janus kinase 2 (JAK2) gene in HSCs that renders this kinase constitutively active, leading to uncontrolled cell expansion. The bone marrow (BM) microenvironment might contribute to the clinical outcomes of this common event. We previously showed that BM nestin+ mesenchymal stem cells (MSCs) innervated by sympathetic nerve fibres regulate normal HSCs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
2 Samples
Download data: TXT
Series
Accession:
GSE55798
ID:
200055798
2.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
3.

Mx1cre-JAK2V617F 6wks post-induction (n=3)

Organism:
Mus musculus
Source name:
Bone marrow nestin+ cells, Mx1-cre;JAK2-V617F
Platform:
GPL11002
Series:
GSE55798 GSE55802
Download data
Sample
Accession:
GSM1346216
ID:
301346216
4.

Control littermates (n=3)

Organism:
Mus musculus
Source name:
Bone marrow nestin+ cells, control
Platform:
GPL11002
Series:
GSE55798 GSE55802
Download data
Sample
Accession:
GSM1346215
ID:
301346215
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Supplemental Content

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