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Items: 5

1.

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome [MBD-seq]

(Submitter supplied) Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depltion of all DNMTs in a pluripotent human tumor cell line, followed by epigenome and transcriptome analysis, revealed DNMT functions in unprecedented detail. DNMT3B occupancy regulates methylation during differentiation, while an unexpected interplay was discovered in which DNMT1 and DNMT3B antithetically regulate methylation and hydroxymethylation in gene bodies, a finding confirmed in other cell types. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL11154
3 Samples
Download data: BED, BIGWIG, TXT
Series
Accession:
GSE54842
ID:
200054842
2.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
3.

NCCIT input all

Organism:
Homo sapiens
Source name:
NCCIT human cells treated with a control non-targeting siRNA
Platform:
GPL11154
Series:
GSE54842 GSE54843
Download data: BED, BIGWIG
Sample
Accession:
GSM1325037
ID:
301325037
4.

NCCIT siNTC 5mC-seq

Organism:
Homo sapiens
Source name:
NCCIT human cells treated with a control non-targeting siRNA
Platform:
GPL11154
Series:
GSE54842 GSE54843
Download data: BED, BIGWIG, TXT
Sample
Accession:
GSM1325036
ID:
301325036
5.

NCCIT siDNMT3B 5mC-seq

Organism:
Homo sapiens
Source name:
NCCIT human cells depleted of DNMT3B by siRNA
Platform:
GPL11154
Series:
GSE54842 GSE54843
Download data: BED, BIGWIG, TXT
Sample
Accession:
GSM1325035
ID:
301325035
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Supplemental Content

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