GSE52588[Accession] - GEO DataSets - NCBI

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Select item 2000525881.

Identification of a DNA methylation signature in blood from subjects affected by Down syndrome

(Submitter supplied) Down syndrome is characterized by a wide spectrum of clinical signs, which include cognitive and endocrine disorders and haematological abnormalities. Although it is well established that the causative defect of Down syndrome is the trisomy of chromosome 21, the molecular bases of Down syndrome phenotype are still largely unknown. We used the Infinium HumanMethylation450 BeadChip to investigate DNA methylation patterns in whole blood from 29 subjects affected by Down syndrome (DS), using their healthy relatives as controls (mothers and unaffected siblings). more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL13534
87 Samples

Download data: TXT

Series

Accession:: GSE52588

ID:: 200052588

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000135342.

Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

(Submitter supplied) 1 difference between HumanMethylation450_15017482_v.1.1.bpm and HumanMethylation450_15017482_v.1.2.bpm: 1.1: 41636384,NEGATIVE,-99,Negative 604 1.2: 41636384,RESTORATION,Green,Restore Protocol: See manufacturer's website

Organism:: Homo sapiens

1645 Series
1 Related Platform
117272 Samples

Download data: BPM, CSV, TXT, XLSX

Platform

Accession:: GPL13534

ID:: 100013534

Select item 3012722083.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2018

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2018

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272208

ID:: 301272208

Select item 3012722074.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2043

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2043

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272207

ID:: 301272207

Select item 3012722065.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2037

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2037

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272206

ID:: 301272206

Select item 3012722056.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2030

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2030

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272205

ID:: 301272205

Select item 3012722047.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2029

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2029

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272204

ID:: 301272204

Select item 3012722038.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2026

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2026

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272203

ID:: 301272203

Select item 3012722029.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2022

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2022

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272202

ID:: 301272202

Select item 30127220110.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2021

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2021

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272201

ID:: 301272201

Select item 30127220011.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2019

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2019

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272200

ID:: 301272200

Select item 30127219912.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2016

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2016

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272199

ID:: 301272199

Select item 30127219813.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2014

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2014

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272198

ID:: 301272198

Select item 30127219714.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2006

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2006

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272197

ID:: 301272197

Select item 30127219615.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2005

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2005

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272196

ID:: 301272196

Select item 30127219516.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2002

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2002

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272195

ID:: 301272195

Select item 30127219417.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2052

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2052

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272194

ID:: 301272194

Select item 30127219318.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2046

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2046

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272193

ID:: 301272193

Select item 30127219219.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2042

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2042

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272192

ID:: 301272192

Select item 30127219120.

genomic DNA from peripheral blood, mother of a subject affected by Down syndrome, 2038

Organism:: Homo sapiens

Source name:: peripheral whole blood, subject 2038

Platform:: GPL13534
Series:: GSE52588

Sample

Accession:: GSM1272191

ID:: 301272191

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