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Items: 11

1.

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)

(Submitter supplied) Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin (Htt) expression. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
8 Samples
Download data: BW
Series
Accession:
GSE48960
ID:
200048960

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Mus musculus)

Organism:
Mus musculus
8082 Series
183912 Samples
Download data
Platform
Accession:
GPL13112
ID:
100013112

3.

Illumina Genome Analyzer IIx (Mus musculus)

Organism:
Mus musculus
890 Series
7694 Samples
Download data
Platform
Accession:
GPL11002
ID:
100011002

4.

ChIP_R6-2_H3K4me3_8wks_str_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2, striatum, 8 weeks
Platform:
GPL13112
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187628
ID:
301187628

SRA Run Selector

5.

ChIP_WT_H3K4me3_8wks_str_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2 wildtype littermate, striatum, 8 weeks
Platform:
GPL13112
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187627
ID:
301187627

SRA Run Selector

6.

ChIP_R6-2_H3K4me3_8wks_ctx_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2, cortex, 8 weeks
Platform:
GPL13112
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187624
ID:
301187624

SRA Run Selector

7.

ChIP_WT_H3K4me3_8wks_ctx_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2 wildtype littermate, cortex, 8 weeks
Platform:
GPL13112
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187623
ID:
301187623

SRA Run Selector

8.

ChIP_R6-2_H3K4me3_12wks_str_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2, striatum, 12 weeks
Platform:
GPL11002
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187630
ID:
301187630

SRA Run Selector

9.

ChIP_WT_H3K4me3_12wks_str_rep1_rep2

Organism:
Mus musculus
Source name:
R6/2 wildtype littermate, striatum, 12 weeks
Platform:
GPL11002
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187629
ID:
301187629

SRA Run Selector

10.

ChIP_R6-2_H3K4me3_12wks_ctx_rep1_rep2_rep3

Organism:
Mus musculus
Source name:
R6/2, cortex, 12 weeks
Platform:
GPL11002
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187626
ID:
301187626

SRA Run Selector

11.

ChIP_WT_H3K4me3_12wks_ctx_rep1_rep2_rep3

Organism:
Mus musculus
Source name:
R6/2 wildtype littermate, cortex, 12 weeks
Platform:
GPL11002
Series:
GSE48960 GSE48963
Download data: BW
Sample
Accession:
GSM1187625
ID:
301187625

SRA Run Selector

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