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Items: 14

1.

Targeted disruption of Hotair leads to homeotic transformation and de-repression of imprinted genes [RNA-Seq, ChIP-Seq]

(Submitter supplied) Long noncoding RNAs (lncRNAs) are thought to be prevalent regulators of gene expression, but the consequences of lncRNA inactivation in vivo are mostly unknown. Here we show that targeted deletion of mouse Hotair lncRNA leads to de-repression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones. RNA-seq and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and multiple imprinted loci such as Dlk1-Meg3 and Igf2-H19. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11002
12 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE48005
ID:
200048005
2.

Illumina Genome Analyzer IIx (Mus musculus)

Platform
Accession:
GPL11002
ID:
100011002
3.

chipseq KO H3K27me3

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data: BEDGRAPH
Sample
Accession:
GSM1164903
ID:
301164903
4.

chipseq WT H3K27me3

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair wildtype
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data: BEDGRAPH
Sample
Accession:
GSM1164902
ID:
301164902
5.

chipseq KO H3K4me3

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data: BEDGRAPH
Sample
Accession:
GSM1164901
ID:
301164901
6.

chipseq WT H3K4me3

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair wildtype
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data: BEDGRAPH
Sample
Accession:
GSM1164900
ID:
301164900
7.

chipseq KO input

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164899
ID:
301164899
8.

chipseq WT input

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair wildtype
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164898
ID:
301164898
9.

rnaseq ko2

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164897
ID:
301164897
10.

rnaseq ko1

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair knockout
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164896
ID:
301164896
11.

rnaseq het2

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair heterozygous
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164895
ID:
301164895
12.

rnaseq het1

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair heterozygous
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164894
ID:
301164894
13.

rnaseq wt2

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair wildtype
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164893
ID:
301164893
14.

rnaseq wt1

Organism:
Mus musculus
Source name:
neonatal tail tip fibroblasts, Hotair wildtype
Platform:
GPL11002
Series:
GSE48005 GSE48007
Download data
Sample
Accession:
GSM1164892
ID:
301164892
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Supplemental Content

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