GSE45284[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2000452841.

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (RNA-Seq)

(Submitter supplied) Protein Arginine MethylTransferase 5 (PRMT5) is known to mediate epigenetic control on chromatin and to functionally regulate components of the splicing machinery. In this study we show that selective deletion of PRMT5 in different organs leads to cell cycle arrest and apoptosis. At the molecular level, PRMT5 depletion results in reduced methylation of Sm proteins, aberrant constitutive splicing and in the Alternative Splicing (AS) of specific mRNAs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE45284

ID:: 200045284

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000131122.

Illumina HiSeq 2000 (Mus musculus)

Organism:: Mus musculus

8391 Series
189311 Samples

Platform

Accession:: GPL13112

ID:: 100013112

Select item 3011007513.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100751

ID:: 301100751

SRA Run Selector

Select item 3011007504.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100750

ID:: 301100750

SRA Run Selector

Select item 3011007495.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100749

ID:: 301100749

SRA Run Selector

Select item 3011007486.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100748

ID:: 301100748

SRA Run Selector

Select item 3011007477.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100747

ID:: 301100747

SRA Run Selector

Select item 3011007468.

Organism:: Mus musculus

Source name:: Mouse Embryonic Fibroblasts

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100746

ID:: 301100746

SRA Run Selector

Select item 3011007459.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100745

ID:: 301100745

SRA Run Selector

Select item 30110074410.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100744

ID:: 301100744

SRA Run Selector

Select item 30110074311.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100743

ID:: 301100743

SRA Run Selector

Select item 30110074212.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100742

ID:: 301100742

SRA Run Selector

Select item 30110074113.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100741

ID:: 301100741

SRA Run Selector

Select item 30110074014.

Organism:: Mus musculus

Source name:: Neural progenitor cells

Platform:: GPL13112
Series:: GSE45284 GSE45285

Sample

Accession:: GSM1100740

ID:: 301100740

SRA Run Selector

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