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Items: 6

1.

TET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [DREAM]

(Submitter supplied) We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level increases. TET1-FL-induced 5hmC accumulates at CGI edges, while TET1 knockdown induces methylation spreading from methylated edges into hypomethylated CGIs. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL9115
4 Samples
Download data: TXT
Series
Accession:
GSE44038
ID:
200044038

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina Genome Analyzer II (Homo sapiens)

Organism:
Homo sapiens
755 Series
6121 Samples
Download data
Platform
Accession:
GPL9115
ID:
100009115

3.

TET1-FL_DREAM

Organism:
Homo sapiens
Source name:
HEK293T cells
Platform:
GPL9115
Series:
GSE44038 GSE44039
Download data: TXT
Sample
Accession:
GSM1077165
ID:
301077165

SRA Run Selector

4.

TET1-CD_DREAM

Organism:
Homo sapiens
Source name:
HEK293T cells
Platform:
GPL9115
Series:
GSE44038 GSE44039
Download data: TXT
Sample
Accession:
GSM1077164
ID:
301077164

SRA Run Selector

5.

mTET1-FL_DREAM

Organism:
Homo sapiens
Source name:
HEK293T cells
Platform:
GPL9115
Series:
GSE44038 GSE44039
Download data: TXT
Sample
Accession:
GSM1077163
ID:
301077163

SRA Run Selector

6.

mTET1-CD_DREAM

Organism:
Homo sapiens
Source name:
HEK293T cells
Platform:
GPL9115
Series:
GSE44038 GSE44039
Download data: TXT
Sample
Accession:
GSM1077162
ID:
301077162

SRA Run Selector

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db=gds|term=GSE44038[Accession]|query=1|qty=2|blobid=MCID_6752915f63e4d51a4972f1fa|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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