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Items: 1 to 20 of 21

1.

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

(Submitter supplied) TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these genetic invaders. In TRIM28-depleted ES cells, repressive chromatin marks at ERVs are replaced by histone modifications typical of active enhancers, stimulating transcription of nearby cellular genes, notably those harboring bivalent promoters. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL13112
18 Samples
Download data: BED, TXT, XLS
Series
Accession:
GSE41903
ID:
200041903

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Mus musculus)

Organism:
Mus musculus
8067 Series
183768 Samples
Download data
Platform
Accession:
GPL13112
ID:
100013112

3.

Illumina Genome Analyzer II (Mus musculus)

Organism:
Mus musculus
800 Series
5946 Samples
Download data
Platform
Accession:
GPL9250
ID:
100009250

4.

KAP1 ChIP: KAP1 KO IP

Organism:
Mus musculus
Source name:
KAP1 ChIP: KAP1 KO IP
Platform:
GPL9250
Series:
GSE41903
Download data: BED
Sample
Accession:
GSM1032199
ID:
301032199

SRA Run Selector

5.

KAP1 ChIP: KAP1 WT IP

Organism:
Mus musculus
Source name:
KAP1 ChIP: KAP1 WT IP
Platform:
GPL9250
Series:
GSE41903
Download data: BED
Sample
Accession:
GSM1032198
ID:
301032198

SRA Run Selector

6.

KAP1 ChIP: KAP1 KO TI

Organism:
Mus musculus
Source name:
KAP1 ChIP: KAP1 KO TI
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032197
ID:
301032197

SRA Run Selector

7.

KAP1 ChIP: KAP1 WT TI

Organism:
Mus musculus
Source name:
KAP1 ChIP: KAP1 WT TI
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032196
ID:
301032196

SRA Run Selector

8.

mRNA-seq: MEF KAP1 KO

Organism:
Mus musculus
Source name:
mRNA-seq: MEF KAP1 KO
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032185
ID:
301032185

SRA Run Selector

9.

mRNA-seq: MEF KAP1 WT

Organism:
Mus musculus
Source name:
mRNA-seq: MEF KAP1 WT
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032184
ID:
301032184

SRA Run Selector

10.

mRNA-seq: ES KAP1 KO (ES3 cells)

Organism:
Mus musculus
Source name:
mRNA-seq: ES KAP1 KO (ES3 cells)
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032183
ID:
301032183

SRA Run Selector

11.

mRNA-seq: ES KAP1 WT (ES3 cells)

Organism:
Mus musculus
Source name:
mRNA-seq: ES KAP1 WT (ES3 cells)
Platform:
GPL9250
Series:
GSE41903
Download data
Sample
Accession:
GSM1032182
ID:
301032182

SRA Run Selector

12.

H3K27ac ChIP: KAP1 KD IP

Organism:
Mus musculus
Source name:
H3K27ac ChIP: KAP1 KD IP
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032195
ID:
301032195

SRA Run Selector

13.

H3K27ac ChIP: KAP1 WT IP

Organism:
Mus musculus
Source name:
H3K27ac ChIP: KAP1 WT IP
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032194
ID:
301032194

SRA Run Selector

14.

H3K27ac ChIP: KAP1 KD TI

Organism:
Mus musculus
Source name:
H3K27ac ChIP: KAP1 KD TI
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032193
ID:
301032193

SRA Run Selector

15.

H3K27ac ChIP: KAP1 WT TI

Organism:
Mus musculus
Source name:
H3K27ac ChIP: KAP1 WT TI
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032192
ID:
301032192

SRA Run Selector

16.

H3K9me3 ChIP: KAP1 KO IP

Organism:
Mus musculus
Source name:
H3K9me3 ChIP: KAP1 KO IP
Platform:
GPL13112
Series:
GSE41903
Download data: BED
Sample
Accession:
GSM1032191
ID:
301032191

SRA Run Selector

17.

H3K9me3 ChIP: KAP1 WT IP

Organism:
Mus musculus
Source name:
H3K9me3 ChIP: KAP1 WT IP
Platform:
GPL13112
Series:
GSE41903
Download data: BED
Sample
Accession:
GSM1032190
ID:
301032190

SRA Run Selector

18.

H3K9me3 ChIP: KAP1 KO TI

Organism:
Mus musculus
Source name:
H3K9me3 ChIP: KAP1 KO TI
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032189
ID:
301032189

SRA Run Selector

19.

H3K9me3 ChIP: KAP1 WT TI

Organism:
Mus musculus
Source name:
H3K9me3 ChIP: KAP1 WT TI
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032188
ID:
301032188

SRA Run Selector

20.

mRNA-seq: ES KAP1 KD (Rex1GFP ES cells)

Organism:
Mus musculus
Source name:
mRNA-seq: ES KAP1 KD (Rex1GFP ES cells)
Platform:
GPL13112
Series:
GSE41903
Download data
Sample
Accession:
GSM1032187
ID:
301032187

SRA Run Selector

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