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Items: 12

1.

Ca2+-dependent Transcription Patterns in Human Cerebrovascular Smooth Muscle

(Submitter supplied) Altered Ca2+ handling has both immediate physiological effects and long-term genomic effects on vascular smooth muscle function. Previously we have shown that elevation of cytoplasmic Ca2+ through voltage-dependent Ca2+ channels (VDCCs) or store-operated Ca2+ channels (SOCCs) results in phosphorylation of the Ca2+/cAMP response element binding protein (CREB) in cerebral arteries. Here we demonstrate that stimulation of these different Ca2+ influx pathways results in transcriptional activation of a distinct, yet overlapping set of genes, and that the induction of selected CRE-regulated genes is prevented by the addition of corresponding Ca2+ channel blockers. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1783
Platform:
GPL96
9 Samples
Download data
Series
Accession:
GSE2883
ID:
200002883
2.
Full record GDS1783

Vascular smooth muscle response to voltage-dependent and store-operated calcium channel activation

Analysis of cerebral vascular smooth muscle cells after activation of voltage-dependent (VDCCs) or store-operated calcium channels (SOCCs). VDCCs activated by K+ depolarization and SOCCs by thapsigargin. Results provide insight into the effect of different calcium signals on gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL96
Series:
GSE2883
9 Samples
Download data
DataSet
Accession:
GDS1783
ID:
1783
3.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...
Organism:
Homo sapiens
364 DataSets
1125 Series
11 Related Platforms
42430 Samples
Download data
Platform
Accession:
GPL96
ID:
100000096
4.

HSVMC_HighK+_rep3

Organism:
Homo sapiens
Source name:
cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63086
ID:
300063086
5.

HSVMC_HighK+_rep2

Organism:
Homo sapiens
Source name:
cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63084
ID:
300063084
6.

HSVMC_HighK+_rep1

Organism:
Homo sapiens
Source name:
cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63083
ID:
300063083
7.

HVSMC_ Thapsigargin_treated_rep3

Organism:
Homo sapiens
Source name:
human cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63082
ID:
300063082
8.

HVSMC_ Thapsigargin_treated_rep2

Organism:
Homo sapiens
Source name:
human cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63081
ID:
300063081
9.

HVSMC_ Thapsigargin_treated_rep1

Organism:
Homo sapiens
Source name:
human cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63080
ID:
300063080
10.

HVSMC_Control_rep3

Organism:
Homo sapiens
Source name:
human cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63078
ID:
300063078
11.

HVSMC_Control_rep2

Organism:
Homo sapiens
Source name:
human cerebral artery
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63077
ID:
300063077
12.

HVSMC_Control_rep1

Organism:
Homo sapiens
Source name:
Human cerebral vascular smooth muscle cells (hcVSMCs) (passages 2-4) were obtained from human cerebral artery explants
Platform:
GPL96
Series:
GSE2883
Dataset:
GDS1783
Download data
Sample
Accession:
GSM63074
ID:
300063074
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