GSE268179[Accession] - GEO DataSets - NCBI

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Select item 2002681791.

Large-scale screen of novel zebrafish retinal ganglion cell ablation model reveals genetic regulation of retinal regeneration is context specific

(Submitter supplied) Many genes are known to regulate Müller glia (MG)-dependent retinal regeneration following widespread tissue damage. Conversely, genes controlling regeneration following limited retinal cell loss, per degenerative disease, are undefined. Studying regeneration in the context of selective cell loss is important as evidence suggests injury specifics inform the regenerative process. Here, transgenic zebrafish enabling inducible selective retinal ganglion cell (RGC) ablation were combined with single cell multiomics and CRISPR/Cas9-based knockout methods to screen 101 genes for effects on RGC regeneration. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24995
20 Samples

Download data: H5, MTX, TBI, TSV

Series

Accession:: GSE268179

ID:: 200268179

Select item 1000249952.

Illumina NovaSeq 6000 (Danio rerio)

Organism:: Danio rerio

381 Series
5513 Samples

Platform

Accession:: GPL24995

ID:: 100024995

Select item 3082874493.

Multiome rgc:ntr 24h ablation ascl1a KO day 7 ATAC

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: TBI, TSV

Sample

Accession:: GSM8287449

ID:: 308287449

SRA Run Selector

Select item 3082874484.

Multiome rgc:ntr 24h ablation ascl1a KO day 7 RNA

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287448

ID:: 308287448

SRA Run Selector

Select item 3082874475.

Multiome rgc:ntr 24h ablation wildtype day 7 ATAC

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: TBI, TSV

Sample

Accession:: GSM8287447

ID:: 308287447

SRA Run Selector

Select item 3082874466.

Multiome rgc:ntr 24h ablation wildtype day 7 RNA

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287446

ID:: 308287446

SRA Run Selector

Select item 3082874457.

Multiome rgc:ntr preablation ascl1a KO day 5 ATAC

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: TBI, TSV

Sample

Accession:: GSM8287445

ID:: 308287445

SRA Run Selector

Select item 3082874448.

Multiome rgc:ntr preablation wildtype control day 5 ATAC

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: TBI, TSV

Sample

Accession:: GSM8287444

ID:: 308287444

SRA Run Selector

Select item 3082874439.

Multiome rgc:ntr preablation ascl1a KO day 5 RNA

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287443

ID:: 308287443

SRA Run Selector

Select item 30828744210.

Multiome rgc:ntr preablation wildtype control day 5 RNA

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287442

ID:: 308287442

SRA Run Selector

Select item 30828744111.

Ablated rgc:ntr day 9 72h mtz

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287441

ID:: 308287441

SRA Run Selector

Select item 30828744012.

Ablated rgc:ntr day 6 12h mtz

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287440

ID:: 308287440

SRA Run Selector

Select item 30828743913.

Unablated rgc:ntr day 9

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287439

ID:: 308287439

SRA Run Selector

Select item 30828743814.

Unablated rgc:ntr day 6

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: MTX, TSV

Sample

Accession:: GSM8287438

ID:: 308287438

SRA Run Selector

Select item 30828743715.

Ablated rgc:ntr day 7 24h mtz

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287437

ID:: 308287437

SRA Run Selector

Select item 30828743616.

Unablated rgc:ntr day 7

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287436

ID:: 308287436

SRA Run Selector

Select item 30828743517.

Ablated rgc:ntr day 8 48h mtz

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Sample

Accession:: GSM8287435

ID:: 308287435

SRA Run Selector

Select item 30828743418.

Unablated rgc:ntr day 8

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: MTX, TSV

Sample

Accession:: GSM8287434

ID:: 308287434

SRA Run Selector

Select item 30828743319.

Ablated rod:ntr day 7 48h mtz, replicate 2

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287433

ID:: 308287433

SRA Run Selector

Select item 30828743220.

Unablated rod:ntr day 7, replicate 2

Organism:: Danio rerio

Source name:: Eye

Platform:: GPL24995
Series:: GSE268179

Download data: H5

Sample

Accession:: GSM8287432

ID:: 308287432

SRA Run Selector

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