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Items: 8

1.

PFKFB3 drives renal fibrosis through promoting histone lactylation-mediated NF- B activation [CUT&Tag]

(Submitter supplied) Persistently elevated glycolysis in kidney has been demonstrated to promote chronic kidney disease. However, the underlying mechanism remains largely unclear. Here, we observed that PFKFB3, a key glycolytic enzyme, was remarkably induced in kidney proximal tubular cells following ischemia-reperfusion injury in mice, as well as in multiple etiologies of chronic kidney disease patients. Proximal tubular epithelial-specific deletion of PFKFB3 significantly reduced renal lactate levels, mitigated inflammation and fibrosis, and preserved renal function in the IRI mouse model. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: BW
Series
Accession:
GSE266243
ID:
200266243

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
13930 Series
690072 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

IRI_4，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243005
ID:
308243005

SRA Run Selector

4.

IRI_3，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243004
ID:
308243004

SRA Run Selector

5.

IRI_2，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243003
ID:
308243003

SRA Run Selector

6.

IRI_1，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243002
ID:
308243002

SRA Run Selector

7.

Sham_2，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243001
ID:
308243001

SRA Run Selector

8.

Sham_1，kidney,H4K12la

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266243
Download data: BW
Sample
Accession:
GSM8243000
ID:
308243000

SRA Run Selector

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db=gds|term=GSE266243[Accession]|query=1|qty=2|blobid=MCID_670f0568c7d3ca20d50f2bad|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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