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Items: 10

1.

Epigenetic and transcriptomic alterations in key inflammatory pathways are established in RUNX1 deficient hematopoietic progenitors and are propagated to neutrophils [HI-C]

(Submitter supplied) Epigenome and transcriptome characterization of RUNX1 deficient hematopoietic cells. We hypothesized that epigenetic alterations in key inflammatory pathway genes are acquired in RUNX1 deficient granulocyte-monocyte progenitors (GMPs) and are propagated to neutrophils. We deleted RUNX1 using Cebpa-Cre, which deletes primarily in GMPs. We analyzed the basal transcriptional changes caused by the loss of RUNX1 in purified GMPs and neutrophils by bulk RNA-seq. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL24247
8 Samples
Download data: BED, MATRIX
Series
Accession:
GSE234847
ID:
200234847
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

PMN_WT_B_HIC

Organism:
Mus musculus
Source name:
BM Neutrophils
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data
Sample
Accession:
GSM7475849
ID:
307475849
4.

PMN_WT_A_HIC

Organism:
Mus musculus
Source name:
BM Neutrophils
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data: MATRIX
Sample
Accession:
GSM7475848
ID:
307475848
5.

PMN_KO_B_HIC

Organism:
Mus musculus
Source name:
BM Neutrophils
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data
Sample
Accession:
GSM7475847
ID:
307475847
6.

PMN_KO_A_HIC

Organism:
Mus musculus
Source name:
BM Neutrophils
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data: MATRIX
Sample
Accession:
GSM7475846
ID:
307475846
7.

GMP_WT_B_HIC

Organism:
Mus musculus
Source name:
BM GMPs
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data
Sample
Accession:
GSM7475845
ID:
307475845
8.

GMP_WT_A_HIC

Organism:
Mus musculus
Source name:
BM GMPs
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data: MATRIX
Sample
Accession:
GSM7475844
ID:
307475844
9.

GMP_KO_B_HIC

Organism:
Mus musculus
Source name:
BM GMPs
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data
Sample
Accession:
GSM7475843
ID:
307475843
10.

GMP_KO_A_HIC

Organism:
Mus musculus
Source name:
BM GMPs
Platform:
GPL24247
Series:
GSE221427 GSE234847
Download data: MATRIX
Sample
Accession:
GSM7475842
ID:
307475842
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Supplemental Content

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