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Items: 14

1.

Double-stranded RNA triggers a distinct integrated stress response in the early embryo [cas9 tol2]

(Submitter supplied) Gene functional study and the emerging mRNA therapy technology heavily rely on in vitro transcribed (IVT) mRNA, but the double-stranded RNA (dsRNA) by-product generated during IVT is often recognized by cells as a marker of virus replication, leading to the integrated stress response (ISR).The biological effects of dsRNA in undifferentiated cells differ significantly from those of differentiated counterparts.Here, we found that dsRNA triggered an unprecedented ISR in zebrafish early embryos, leading to developmental delay, severe cell necrosis, and lethal malformations.Mechanistically, dsRNA stimulation caused a PKR-eIF2α independent global translation inhibition and a burst of p53 signaling. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
12 Samples
Download data: XLS, XLSX
Series
Accession:
GSE234227
ID:
200234227

2.

Illumina HiSeq 2000 (Danio rerio)

Organism:
Danio rerio
297 Series
4675 Samples
Download data
Platform
Accession:
GPL14875
ID:
100014875

3.

TP450-3

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457634
ID:
307457634

SRA Run Selector

4.

TP450-2

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457633
ID:
307457633

SRA Run Selector

5.

TP450-1

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457632
ID:
307457632

SRA Run Selector

6.

Uninj-3

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457631
ID:
307457631

SRA Run Selector

7.

Uninj-2

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457630
ID:
307457630

SRA Run Selector

8.

Uninj-1

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457629
ID:
307457629

SRA Run Selector

9.

cas9-5hpf-3

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457628
ID:
307457628

SRA Run Selector

10.

cas9-5hpf-2

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457627
ID:
307457627

SRA Run Selector

11.

cas9-5hpf-1

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457626
ID:
307457626

SRA Run Selector

12.

uninj-5hpf-3

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457625
ID:
307457625

SRA Run Selector

13.

uninj-5hpf-2

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457624
ID:
307457624

SRA Run Selector

14.

uninj-5hpf-1

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457623
ID:
307457623

SRA Run Selector

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db=gds|term=GSE234227[Accession]|query=1|qty=2|blobid=MCID_674e9a77c7e616537b7e90da|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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