GEO DataSets

(Submitter supplied) Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, lung adenocarcinoma (LUAD) cells transform into neuroendocrinal (NE) cell-like tumor cells. However, the mechanisms of NE cell plasticity remain unclear. Depletion of CRACD tumor suppressor results in the de-repression of NE-related gene expression in the pulmonary epithelium. Similarly, Cracd KO augments intratumoral heterogeneity with upregulation of NE markers in LUAD animal models. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

2 Samples

Download data: H5AD