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1.

Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse Protamine 1 [scRNA-Seq]

(Submitter supplied) Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. However, phylogenetic analysis reveals several non-arginine residues conserved within, but not across species. The significance of these residues or post-translational modifications are poorly understood. Here, we investigated the functional role of K49, a rodent-specific lysine residue in mouse protamine 1 (P1) that is acetylated early in spermiogenesis and retained in sperm. In vivo, alanine substitution (P1 K49A) results in loss of programmatic histone retention, decreased sperm motility, decreased male fertility, and in zygotes, premature P1 removal from paternal chromatin, altered DNA replication, and embryonic arrest. In vitro, P1 K49A decreases protamine-DNA binding and alters DNA compaction/decompaction kinetics. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
48 Samples
Download data: TXT
Series
Accession:
GSE225270
ID:
200225270

PubMed Full text in PMC Similar studies

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
13776 Series
688309 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

K49A-24 dot dot_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043071
ID:
307043071

SRA Run Selector

4.

K49A-18_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043070
ID:
307043070

SRA Run Selector

5.

K49A-12_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043069
ID:
307043069

SRA Run Selector

6.

K49A-6_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043068
ID:
307043068

SRA Run Selector

7.

WT-24_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043067
ID:
307043067

SRA Run Selector

8.

WT-18_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043066
ID:
307043066

SRA Run Selector

9.

WT-12_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043065
ID:
307043065

SRA Run Selector

10.

WT-6_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043064
ID:
307043064

SRA Run Selector

11.

K49A-23 dot_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043063
ID:
307043063

SRA Run Selector

12.

K49A-17_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043062
ID:
307043062

SRA Run Selector

13.

K49A-11_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043061
ID:
307043061

SRA Run Selector

14.

K49A-5_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043060
ID:
307043060

SRA Run Selector

15.

WT-23_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043059
ID:
307043059

SRA Run Selector

16.

WT-17_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043058
ID:
307043058

SRA Run Selector

17.

WT-11_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043057
ID:
307043057

SRA Run Selector

18.

WT-5_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043056
ID:
307043056

SRA Run Selector

19.

K49A-22 dot_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043055
ID:
307043055

SRA Run Selector

20.

K49A-16_2-cell

Organism:
Mus musculus
Source name:
embryo
Platform:
GPL24247
Series:
GSE225270 GSE225271
Download data: TXT
Sample
Accession:
GSM7043054
ID:
307043054

SRA Run Selector

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db=gds|term=GSE225270[Accession]|query=1|qty=2|blobid=MCID_66ff8e8375ef1969295c47cf|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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