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Items: 1 to 20 of 80

1.

Age-associated chromatin re-organization in progenitor B cells

(Submitter supplied) Three-dimensional (3D) organization of the genome is essential for precise patterns of gene expression required for biological processes, however its role in physiological aging is not known.Here we show that large scale chromatin re-organization distinguishes bone marrow progenitor (pro-) B cells of old mice from that of young mice.These changes result in increased interactions at the compartment level and reduced interactions within topologically associated domains (TADs).One genomic region that transitions from compartment A to B with age contains the gene encoding Ebf1, a key regulator of normal B cell development.Genetically reducing Ebf1 recapitulates some features of old pro-B cells.TADs that are most reduced with age also harbor genes important for function and development of pro-B cells, including the immunoglobulin heavy chain (IgH) gene locus.Weaker intra-TAD interactions at IgH correlate with reduced utilization of distally located variable gene segments in VDJ recombination.Our observations implicate 3D chromatin re-organization as a major driver of pro-B cell phenotypes that impair B lymphopoiesis with age.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Genome variation profiling by high throughput sequencing
Platforms:
GPL16417 GPL19057 GPL24247
76 Samples
Download data: BED, BEDPE, TXT
Series
Accession:
GSE214438
ID:
200214438
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
5.

VDJ-seq_Old_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data: TXT
Sample
Accession:
GSM7921775
ID:
307921775
6.

VDJ-seq_Old_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data: TXT
Sample
Accession:
GSM7921774
ID:
307921774
7.

RNA-seq_GFP_Young_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921773
ID:
307921773
8.

RNA-seq_GFP_Young_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921772
ID:
307921772
9.

RNA-seq_GFP_Old_rep3

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921771
ID:
307921771
10.

RNA-seq_GFP_Old_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921770
ID:
307921770
11.

RNA-seq_GFP_Old_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921769
ID:
307921769
12.

RNA-seq_Ebf1OE_Young_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921768
ID:
307921768
13.

RNA-seq_Ebf1OE_Young_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921767
ID:
307921767
14.

RNA-seq_Ebf1OE_Old_rep3

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921766
ID:
307921766
15.

RNA-seq_Ebf1OE_Old_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921765
ID:
307921765
16.

RNA-seq_Ebf1OE_Old_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921764
ID:
307921764
17.

RNA-seq_Wapl+_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921763
ID:
307921763
18.

RNA-seq_Wapl+_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921762
ID:
307921762
19.

RNA-seq_D345Ctrl_rep2

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921761
ID:
307921761
20.

RNA-seq_D345Ctrl_rep1

Organism:
Mus musculus
Source name:
progenitor B cells
Platform:
GPL24247
Series:
GSE214438
Download data
Sample
Accession:
GSM7921760
ID:
307921760
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Supplemental Content

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