GSE203321[Accession] - GEO DataSets - NCBI

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Items: 4

Select item 2002033211.

BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state [scRNA-Seq]

(Submitter supplied) Chromatin remodeling caused by SWI/SNF (BAF) complexes is essential for regulating cell fates. Of these, BRD9, an essential component of the non-canonical BAF (ncBAF) complex, is post-transcriptionally decayed in multiple types of cancer, especially in myelodysplastic syndrome (MDS). However, how BRD9 loss or ncBAF disruption alters the HSCs' integrity remains unknown. Here, we identify that Brd9 loss enhances chromatin accessibility, promoting myeloid-lineage skewing at the expense of B cell development in vivo, followed by MDS development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE203321

ID:: 200203321

PubMed Full text in PMC Similar studies

Select item 1000242472.

Illumina NovaSeq 6000 (Mus musculus)

Organism:: Mus musculus

15319 Series
710306 Samples

Platform

Accession:: GPL24247

ID:: 100024247

Select item 3061664613.

Organism:: Mus musculus

Source name:: Lineage- cKit+ bone marrow cells in femora and tibiae

Platform:: GPL24247
Series:: GSE203321 GSE203322

Download data: MTX, TSV

Sample

Accession:: GSM6166461

ID:: 306166461

SRA Run Selector

Select item 3061664604.

Organism:: Mus musculus

Source name:: Lineage- cKit+ bone marrow cells in femora and tibiae

Platform:: GPL24247
Series:: GSE203321 GSE203322

Download data: MTX, TSV

Sample

Accession:: GSM6166460

ID:: 306166460

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GSE203321[Accession] (4)
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