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Items: 8

1.

RNA sequencing of patient derived xenograft sample ALL-811 using prime-seq

(Submitter supplied) We establish a Cre-ERT2-loxP (causes recombination, estrogen receptor mutant T2, locus of X-over P1) based inducible RNAi- (ribonucleic acid interference) mediated gene silencing system in patient-derived xenograft (PDX) models of acute leukemias in vivo. Mimicking anti-cancer therapy in patients, gene inhibition is initiated in mice harboring orthotopic tumors. In fluorochrome guided, competitive in vivo trials, silencing of DUX4 (double homeobox 4) playes an essential role in patients’ leukemias carrying the recently described DUX4-IGH (immunoglobulin heavy chain) translocation, while the downstream mediator DDIT4L (DNA-damage-inducible transcript 4 like) is identified as therapeutic vulnerability.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18460
6 Samples
Download data: TXT
Series
Accession:
GSE182780
ID:
200182780
2.

Illumina HiSeq 1500 (Homo sapiens)

Platform
Accession:
GPL18460
ID:
100018460
3.

TTGTTA_DUX4

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536896
ID:
305536896
4.

CGACGG_CTRL

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536895
ID:
305536895
5.

ACTAAA_CTRL

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536894
ID:
305536894
6.

AATGTA_DUX4

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536893
ID:
305536893
7.

AAGTTA_CTRL

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536892
ID:
305536892
8.

AAATCA_DUX4

Organism:
Homo sapiens
Source name:
ALL PDX line
Platform:
GPL18460
Series:
GSE182780
Download data
Sample
Accession:
GSM5536891
ID:
305536891
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Supplemental Content

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