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Items: 11

1.

A novel oral arginase 1/2 inhibitor enhances the antitumor effect of PD-1 inhibition in murine experimental gliomas by altering the immunosuppressive environment.

(Submitter supplied) Malignant gliomas are common and aggressive primary brain tumors which are incurable by conventional therapies. Immunotherapy with the immune checkpoint inhibitors is not effective due to the highly immunosuppressive tumor microenvironment (TME). Clinical and experimental data show upregulation of Arginase1 (ARG1) expression in rodent and human malignant gliomas. The elevated ARG1 activity leads to depletion of L-arginine required for proliferation of T lymphocytes and natural killer cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
9 Samples
Download data: TAB
Series
Accession:
GSE173865
ID:
200173865
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

CHECK rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282108
ID:
305282108
4.

CHECK rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282107
ID:
305282107
5.

COM rep3

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282106
ID:
305282106
6.

COM rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282105
ID:
305282105
7.

COM rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282104
ID:
305282104
8.

OAT rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282103
ID:
305282103
9.

OAT rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282102
ID:
305282102
10.

CTR rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282101
ID:
305282101
11.

CTR rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282100
ID:
305282100
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