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Items: 11

1.

Parkinson's disease-associated DJ-1 is required for the expression of GDNF receptor Ret in human neuroblastoma cells

(Submitter supplied) DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinson’s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then used functional genomic techniques to identify novel pathways dysregulated by loss of DJ-1 function. Using microarray gene expression profiling, we found that DJ-1 silencing alters the expression of 26 genes, with 10 down-regulated and 16 up-regulated transcripts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3750
Platform:
GPL571
8 Samples
Download data: CEL
Series
Accession:
GSE17204
ID:
200017204
2.
Full record GDS3750

Peroxiredoxin-like peroxidase DJ-1 knockdown effect on neuroblastoma cell line

Analysis of SH-SY5Y neuroblastoma cells depleted of DJ-1, an atypical peroxiredoxin-like peroxidase. Mutations in the gene encoding DJ-1 cause autosomal recessive early-onset Parkinson disease (AREP). Results provide insight into the molecular mechanisms underlying DJ-1-mediated PD pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL571
Series:
GSE17204
8 Samples
Download data: CEL
3.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...
Organism:
Homo sapiens
84 DataSets
638 Series
12 Related Platforms
24352 Samples
Download data
Platform
Accession:
GPL571
ID:
100000571
4.

Neuroblastoma SH-SY5Y cells_cloneM_scramble control_replicate2

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, transfected with scramble control
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430346
ID:
300430346
5.

Neuroblastoma SH-SY5Y cells_cloneM_scramble control_replicate1

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, transfected with scramble control
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430345
ID:
300430345
6.

Neuroblastoma SH-SY5Y cells_cloneH_scramble control_replicate2

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, transfected with scramble control
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430344
ID:
300430344
7.

Neuroblastoma SH-SY5Y cells_cloneH_scramble control_replicate1

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, transfected with scramble control
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430343
ID:
300430343
8.

Neuroblastoma SH-SY5Y cells_cloneG_stably transfected with RNAi against DJ-1_replicate2

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, stably transfected with RNAi against DJ-1
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430342
ID:
300430342
9.

Neuroblastoma SH-SY5Y cells_cloneG_stably transfected with RNAi against DJ-1_replicate1

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, stably transfected with RNAi against DJ-1
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430341
ID:
300430341
10.

Neuroblastoma SH-SY5Y cells_cloneB_stably transfected with RNAi against DJ-1_replicate2

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, stably transfected with RNAi against DJ-1
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430340
ID:
300430340
11.

Neuroblastoma SH-SY5Y cells_cloneB_stably transfected with RNAi against DJ-1_replicate1

Organism:
Homo sapiens
Source name:
Neuroblastoma SH-SY5Y cells, stably transfected with RNAi against DJ-1
Platform:
GPL571
Series:
GSE17204
Dataset:
GDS3750
Download data: CEL
Sample
Accession:
GSM430339
ID:
300430339
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