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Items: 1 to 20 of 21

1.

TENT5 cytoplasmic non-canonical poly(A) polymerases regulate the innate immune response in animals

(Submitter supplied) Innate immunity, the first line of host defense against pathogens, is tightly regulated both transcriptionally and post-transcriptionally. Through global transcriptome and proteome analyses in Caenorhabditis elegans, we uncover a modulation of the expression of secreted innate immunity effector proteins by TENT5, one of a recently described family of cytoplasmic poly(A) polymerases. Direct RNA sequencing revealed that TENT-5 polyadenylates mRNAs with signal peptide-encoding sequences, that are translated at the endoplasmic reticulum. Loss of tent-5 function makes worms more susceptible to bacterial infection. Importantly, we demonstrate that the function of TENT-5 in innate immunity is evolutionarily conserved, as its orthologs, TENT5A and TENT5C are induced during macrophage activation and polyadenylate mRNAs, some of which are of genes orthologous to C. more...
Organism:
Caenorhabditis elegans; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19757 GPL19057
18 Samples
Download data: TSV
Series
Accession:
GSE163549
ID:
200163549
2.

Illumina NextSeq 500 (Caenorhabditis elegans)

Organism:
Caenorhabditis elegans
207 Series
3347 Samples
Download data
Platform
Accession:
GPL19757
ID:
100019757
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

SA_TENT-5_3

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981586
ID:
304981586
5.

SA_TENT-5_2

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981585
ID:
304981585
6.

SA_TENT-5_1

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981584
ID:
304981584
7.

SA_WT_3

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981583
ID:
304981583
8.

SA_WT_2

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981582
ID:
304981582
9.

SA_WT_1

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981581
ID:
304981581
10.

HB_TENT-5_3

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981580
ID:
304981580
11.

HB_TENT-5_2

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981579
ID:
304981579
12.

HB_TENT-5_1

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981578
ID:
304981578
13.

HB_WT_3

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981577
ID:
304981577
14.

HB_WT_2

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981576
ID:
304981576
15.

HB_WT_1

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
Download data
Sample
Accession:
GSM4981575
ID:
304981575
16.

BMDM_LPS_8h_3

Organism:
Mus musculus
Source name:
bone marrow-derived macrophages
Platform:
GPL19057
Series:
GSE163549
Download data
Sample
Accession:
GSM4981592
ID:
304981592
17.

BMDM_LPS_8h_2

Organism:
Mus musculus
Source name:
bone marrow-derived macrophages
Platform:
GPL19057
Series:
GSE163549
Download data
Sample
Accession:
GSM4981591
ID:
304981591
18.

BMDM_LPS_8h_1

Organism:
Mus musculus
Source name:
bone marrow-derived macrophages
Platform:
GPL19057
Series:
GSE163549
Download data
Sample
Accession:
GSM4981590
ID:
304981590
19.

BMDM_LPS_0h_3

Organism:
Mus musculus
Source name:
bone marrow-derived macrophages
Platform:
GPL19057
Series:
GSE163549
Download data
Sample
Accession:
GSM4981589
ID:
304981589
20.

BMDM_LPS_0h_2

Organism:
Mus musculus
Source name:
bone marrow-derived macrophages
Platform:
GPL19057
Series:
GSE163549
Download data
Sample
Accession:
GSM4981588
ID:
304981588
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