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Items: 8

1.

AKT signaling promotes epigenetic reprogramming via upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.

(Submitter supplied) Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival, and tumorigenesis as well as cellular reprogramming including generation of induced pluripotent stem cells (iPSCs). In this study, we revealed that activation of AKT in somatic cells undergoing reprogramming enhances epigenetic reprogramming. Activated AKT in reprogramming cells triggers elevated anabolic glucose metabolism, and, accordingly, increases the level of α-ketoglutarate (αKG) which is an essential cofactor for the enzymatic activity of the 5-methylcytosine (5mC) dioxygenase TET. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
6 Samples
Download data: CSV
Series
Accession:
GSE161344
ID:
200161344
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

Reprogramming MEFs_10 dpi_+4OHT_rep3 [iPS6]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_+4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905100
ID:
304905100
4.

Reprogramming MEFs_10 dpi_+4OHT_rep2 [iPS5]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_+4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905099
ID:
304905099
5.

Reprogramming MEFs_10 dpi_+4OHT_rep1 [iPS4]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_+4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905098
ID:
304905098
6.

Reprogramming MEFs_10 dpi_-4OHT_rep3 [iPS3]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_-4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905097
ID:
304905097
7.

Reprogramming MEFs_10 dpi_-4OHT_rep2 [iPS2]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_-4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905096
ID:
304905096
8.

Reprogramming MEFs_10 dpi_-4OHT_rep1 [iPS1]

Organism:
Mus musculus
Source name:
Reprogramming MEFs_10 dpi_-4OHT
Platform:
GPL18480
Series:
GSE161344
Download data
Sample
Accession:
GSM4905095
ID:
304905095
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Supplemental Content

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