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Items: 8

1.

System-wide analysis of Dhx36 function in skeletal muscle satellite cells reveals its binding with 5’UTR G4 structure to promote Gnai2 RNA translation [Polysome profiling]

(Submitter supplied) In this study, we deciphered the functions of Dhx36 and related molecular mechanisms in muscle stem cells and muscle regeneration. We found Dhx36 was highly induced in activated muscle stem cells during regeneration induced by injury. Conditional inactivation of Dhx36 in mouse muscle stem cells caused significant impaired regeneration, which was due to the dramatically decreased cell proliferation. Dhx36 was a well-known RNA helicase for binding/unwinding DNA/RNA G-quadruplexes and it was dominantly expressed in cytoplasm of proliferating myoblast. To examine whether Dhx36 regulates translation process, we conducted polysome profiling followed by RNA-seq in WT and Dhx36 KO myoblast cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
6 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE151123
ID:
200151123
2.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
3.

KO_Polysome_associated_Bio_Rep2

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567049
ID:
304567049
4.

KO_Polysome_associated_Bio_Rep1

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567048
ID:
304567048
5.

Dhx36_KO_Total_mRNA

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567047
ID:
304567047
6.

WT_Polysome_associated_Bio_Rep2

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567046
ID:
304567046
7.

WT_Polysome_associated_Bio_Rep1

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567045
ID:
304567045
8.

WT_Total_mRNA

Organism:
Mus musculus
Source name:
C2C12 myoblasts
Platform:
GPL18480
Series:
GSE151123 GSE151124
Download data: FPKM_TRACKING
Sample
Accession:
GSM4567044
ID:
304567044
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Supplemental Content

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