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Items: 11

1.

Genome-wide mapping of 5-hydroxymethylcytosine enrichment in a novel model of 'NAFLD in a Dish'

(Submitter supplied) Human pluriopotent H9 cells were differentiated to hepatocyte-like cells and exposed to a cocktail of lactate, pyruvate and octanoic acid (LPO) for 48 hours. This stimulated development of macrovesicular steatosis, which has previously been reported to impact on mitochondrial metabolism. Under our experimental conditions, we identified rewiring of the TCA cycle linked to macrovesicular steatosis. As key TCA cycle metabolites, alpha-ketoglutarate, succinate and fumarate impact on ten-eleven translocation (TET) enzyme activity, we hypothesised that this rewiring would impact on levels of 5-hydroxymethylcytosine (5hmC) enrichment across the genome. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL17303
9 Samples
Download data: CSV
Series
Accession:
GSE144955
ID:
200144955
2.

Ion Torrent Proton (Homo sapiens)

Platform
Accession:
GPL17303
ID:
100017303
3.

Input LPO

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301426
ID:
304301426
4.

Input Control

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301425
ID:
304301425
5.

IgG

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301424
ID:
304301424
6.

LPO 3

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301423
ID:
304301423
7.

LPO 2

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301422
ID:
304301422
8.

LPO 1

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301421
ID:
304301421
9.

Control 3

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301420
ID:
304301420
10.

Control 2

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301419
ID:
304301419
11.

Control 1

Organism:
Homo sapiens
Source name:
Hepatocyte-like cells
Platform:
GPL17303
Series:
GSE144955
Download data
Sample
Accession:
GSM4301418
ID:
304301418
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