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Items: 6

1.

The nuclear matrix protein SAFB maintains heterochromatin architecture through RNA-dependent phase separation [RIP-seq]

(Submitter supplied) Eukaryotic chromosomes fold into topologically associating domains (TADs), which further gather in active (A) or inactive (B) genomic compartments. Here we show that Scaffold Attachment Factor B (SAFB), a nuclear matrix-associated protein with RNA binding functions, modulates global chromatin condensation in a dosage-dependent manner. Upon the depletion of SAFB, the genome coverage of Lamina-associated-domains (LADs) decreases from 53.33% to 45.93%, and both inter- and intra-TAD chromatin-chromatin interactions in compartment B decrease significantly. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
4 Samples
Download data: TXT
Series
Accession:
GSE141084
ID:
200141084
2.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
3.

SAFB_RIPseq_rep2

Organism:
Mus musculus
Source name:
AML12 SAFB
Platform:
GPL21273
Series:
GSE125037 GSE141084
Download data
Sample
Accession:
GSM4194774
ID:
304194774
4.

SAFB_RIPseq_rep1

Organism:
Mus musculus
Source name:
AML12 SAFB
Platform:
GPL21273
Series:
GSE125037 GSE141084
Download data
Sample
Accession:
GSM4194773
ID:
304194773
5.

IgG_RIPseq_rep2

Organism:
Mus musculus
Source name:
AML12 IgG
Platform:
GPL21273
Series:
GSE125037 GSE141084
Download data
Sample
Accession:
GSM4194772
ID:
304194772
6.

IgG_RIPseq_rep1

Organism:
Mus musculus
Source name:
AML12 IgG
Platform:
GPL21273
Series:
GSE125037 GSE141084
Download data
Sample
Accession:
GSM4194771
ID:
304194771
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Supplemental Content

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