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Items: 6

1.

The nuclear matrix protein SAFB maintains heterochromatin architecture through RNA-dependent phase separation [Hi-C]

(Submitter supplied) Eukaryotic chromosomes fold into topologically associating domains (TADs), which further gather in active (A) or inactive (B) genomic compartments. Here we show that Scaffold Attachment Factor B (SAFB), a nuclear matrix-associated protein with RNA binding functions, modulates global chromatin condensation in a dosage-dependent manner. Upon the depletion of SAFB, the genome coverage of Lamina-associated-domains (LADs) decreases from 53.33% to 45.93%, and both inter- and intra-TAD chromatin-chromatin interactions in compartment B decrease significantly. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL21273
4 Samples
Download data: HIC
Series
Accession:
GSE141080
ID:
200141080
2.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
3.

Hi-C AML12 shSafb-2 AML12

Organism:
Mus musculus
Source name:
Safb KD (shSafb)
Platform:
GPL21273
Series:
GSE125037 GSE141080
Download data: HIC
Sample
Accession:
GSM4194652
ID:
304194652
4.

Hi-C AML12 shSafb-1 AML12

Organism:
Mus musculus
Source name:
Safb KD (shSafb)
Platform:
GPL21273
Series:
GSE125037 GSE141080
Download data: HIC
Sample
Accession:
GSM4194651
ID:
304194651
5.

Hi-C AML12 shCtrl-2

Organism:
Mus musculus
Source name:
shCtrl AML12
Platform:
GPL21273
Series:
GSE125037 GSE141080
Download data: HIC
Sample
Accession:
GSM4194650
ID:
304194650
6.

Hi-C AML12 shCtrl-1

Organism:
Mus musculus
Source name:
shCtrl AML12
Platform:
GPL21273
Series:
GSE125037 GSE141080
Download data: HIC
Sample
Accession:
GSM4194649
ID:
304194649
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Supplemental Content

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